The comparative diagnostic features of canine and human lymphoma

Davis M. Seelig, Anne C. Avery, E. J. Ehrhart, Michael A. Linden

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the humanWorld Health Organization guidelines. While this approach has contributed to an increasing appreciation of the potential biological scope of canine lymphoma, it has also become apparent that the most appropriate diagnostic philosophy must be multimodal, namely by requiring knowledge of microscopic, immunophenotypic, and clinical features before establishing a final disease diagnosis. This review seeks to illustrate the comparative similarities and differences in the diagnosis of canine lymphoma through the presentation of the microscopic and immunophenotypic features of its most common forms.

Original languageEnglish (US)
Article number11
JournalVeterinary Sciences
Issue number2
StatePublished - Jun 1 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors.


  • Canine
  • Comparative oncology
  • Comparative pathology
  • Lymphoma
  • Non-Hodgkin lymphoma


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