The comparative diagnostic features of canine and human lymphoma

Davis M. Seelig, Anne C. Avery, E. J. Ehrhart, Michael A. Linden

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the humanWorld Health Organization guidelines. While this approach has contributed to an increasing appreciation of the potential biological scope of canine lymphoma, it has also become apparent that the most appropriate diagnostic philosophy must be multimodal, namely by requiring knowledge of microscopic, immunophenotypic, and clinical features before establishing a final disease diagnosis. This review seeks to illustrate the comparative similarities and differences in the diagnosis of canine lymphoma through the presentation of the microscopic and immunophenotypic features of its most common forms.

Original languageEnglish (US)
Article number11
JournalVeterinary Sciences
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2016

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lymphoma
Canidae
Lymphoma
dogs
non-Hodgkin lymphoma
Non-Hodgkin's Lymphoma
disease diagnosis
Neoplasms
Animal Models
Dogs
Guidelines
animal models
Incidence
Health
incidence
neoplasms

Keywords

  • Canine
  • Comparative oncology
  • Comparative pathology
  • Lymphoma
  • Non-Hodgkin lymphoma

Cite this

The comparative diagnostic features of canine and human lymphoma. / Seelig, Davis M.; Avery, Anne C.; Ehrhart, E. J.; Linden, Michael A.

In: Veterinary Sciences, Vol. 3, No. 2, 11, 01.06.2016.

Research output: Contribution to journalReview article

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