The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

K. Silventoinen, A. Jelenkovic, Y. Yokoyama, R. Sund, M. Sugawara, M. Tanaka, S. Matsumoto, L. H. Bogl, D. L. Freitas, J. A. Maia, J. V.B. Hjelmborg, S. Aaltonen, M. Piirtola, A. Latvala, L. Calais-Ferreira, V. C. Oliveira, P. H. Ferreira, F. Ji, F. Ning, Z. PangJ. R. Ordoñana, J. F. Sánchez-Romera, L. Colodro-Conde, S. A. Burt, K. L. Klump, N. G. Martin, S. E. Medland, G. W. Montgomery, C. Kandler, T. A. McAdams, T. C. Eley, A. M. Gregory, K. J. Saudino, L. Dubois, M. Boivin, M. Brendgen, G. Dionne, F. Vitaro, A. D. Tarnoki, D. L. Tarnoki, C. M.A. Haworth, R. Plomin, S. Y. Öncel, F. Aliev, E. Medda, L. Nisticò, V. Toccaceli, J. M. Craig, R. Saffery, S. H. Siribaddana, M. Hotopf, A. Sumathipala, F. Rijsdijk, H. U. Jeong, T. Spector, M. Mangino, G. Lachance, M. Gatz, D. A. Butler, W. Gao, C. Yu, L. Li, G. Bayasgalan, D. Narandalai, K. P. Harden, E. M. Tucker-Drob, K. Christensen, A. Skytthe, K. O. Kyvik, C. A. Derom, R. F. Vlietinck, R. J.F. Loos, W. Cozen, A. E. Hwang, T. M. Mack, M. He, X. Ding, J. L. Silberg, H. H. Maes, T. L. Cutler, J. L. Hopper, P. K.E. Magnusson, N. L. Pedersen, A. K. Dahl Aslan, L. A. Baker, C. Tuvblad, M. Bjerregaard-Andersen, H. Beck-Nielsen, M. Sodemann, V. Ullemar, C. Almqvist, Q. Tan, D. Zhang, G. E. Swan, R. Krasnow, K. L. Jang, A. Knafo-Noam, D. Mankuta, L. Abramson, P. Lichtenstein, R. F. Krueger, M. McGue, S. Pahlen, P. Tynelius, F. Rasmussen, G. E. Duncan, D. Buchwald, R. P. Corley, B. M. Huibregtse, T. L. Nelson, K. E. Whitfield, C. E. Franz, W. S. Kremen, M. J. Lyons, S. Ooki, I. Brandt, T. S. Nilsen, J. R. Harris, J. Sung, H. A. Park, J. Lee, S. J. Lee, G. Willemsen, M. Bartels, C. E.M. Van Beijsterveldt, C. H. Llewellyn, A. Fisher, E. Rebato, A. Busjahn, R. Tomizawa, F. Inui, M. Watanabe, C. Honda, N. Sakai, Y. M. Hur, T. I.A. Sorensen, D. I. Boomsma, J. Kaprio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Original languageEnglish (US)
JournalTwin Research and Human Genetics
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Parturition
Birth Weight
Smoking
Term Birth
Education
Dizygotic Twins
Weights and Measures
Social Class
Sample Size
Epidemiologic Studies
Body Mass Index
Databases
Phenotype
Research
Genes

Keywords

  • BMI
  • Twins
  • birth size
  • education
  • height
  • heritability
  • international comparisons

Cite this

The CODATwins Project : The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. / Silventoinen, K.; Jelenkovic, A.; Yokoyama, Y.; Sund, R.; Sugawara, M.; Tanaka, M.; Matsumoto, S.; Bogl, L. H.; Freitas, D. L.; Maia, J. A.; Hjelmborg, J. V.B.; Aaltonen, S.; Piirtola, M.; Latvala, A.; Calais-Ferreira, L.; Oliveira, V. C.; Ferreira, P. H.; Ji, F.; Ning, F.; Pang, Z.; Ordoñana, J. R.; Sánchez-Romera, J. F.; Colodro-Conde, L.; Burt, S. A.; Klump, K. L.; Martin, N. G.; Medland, S. E.; Montgomery, G. W.; Kandler, C.; McAdams, T. A.; Eley, T. C.; Gregory, A. M.; Saudino, K. J.; Dubois, L.; Boivin, M.; Brendgen, M.; Dionne, G.; Vitaro, F.; Tarnoki, A. D.; Tarnoki, D. L.; Haworth, C. M.A.; Plomin, R.; Öncel, S. Y.; Aliev, F.; Medda, E.; Nisticò, L.; Toccaceli, V.; Craig, J. M.; Saffery, R.; Siribaddana, S. H.; Hotopf, M.; Sumathipala, A.; Rijsdijk, F.; Jeong, H. U.; Spector, T.; Mangino, M.; Lachance, G.; Gatz, M.; Butler, D. A.; Gao, W.; Yu, C.; Li, L.; Bayasgalan, G.; Narandalai, D.; Harden, K. P.; Tucker-Drob, E. M.; Christensen, K.; Skytthe, A.; Kyvik, K. O.; Derom, C. A.; Vlietinck, R. F.; Loos, R. J.F.; Cozen, W.; Hwang, A. E.; Mack, T. M.; He, M.; Ding, X.; Silberg, J. L.; Maes, H. H.; Cutler, T. L.; Hopper, J. L.; Magnusson, P. K.E.; Pedersen, N. L.; Dahl Aslan, A. K.; Baker, L. A.; Tuvblad, C.; Bjerregaard-Andersen, M.; Beck-Nielsen, H.; Sodemann, M.; Ullemar, V.; Almqvist, C.; Tan, Q.; Zhang, D.; Swan, G. E.; Krasnow, R.; Jang, K. L.; Knafo-Noam, A.; Mankuta, D.; Abramson, L.; Lichtenstein, P.; Krueger, R. F.; McGue, M.; Pahlen, S.; Tynelius, P.; Rasmussen, F.; Duncan, G. E.; Buchwald, D.; Corley, R. P.; Huibregtse, B. M.; Nelson, T. L.; Whitfield, K. E.; Franz, C. E.; Kremen, W. S.; Lyons, M. J.; Ooki, S.; Brandt, I.; Nilsen, T. S.; Harris, J. R.; Sung, J.; Park, H. A.; Lee, J.; Lee, S. J.; Willemsen, G.; Bartels, M.; Van Beijsterveldt, C. E.M.; Llewellyn, C. H.; Fisher, A.; Rebato, E.; Busjahn, A.; Tomizawa, R.; Inui, F.; Watanabe, M.; Honda, C.; Sakai, N.; Hur, Y. M.; Sorensen, T. I.A.; Boomsma, D. I.; Kaprio, J.

In: Twin Research and Human Genetics, 01.01.2019.

Research output: Contribution to journalArticle

Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Sugawara, M, Tanaka, M, Matsumoto, S, Bogl, LH, Freitas, DL, Maia, JA, Hjelmborg, JVB, Aaltonen, S, Piirtola, M, Latvala, A, Calais-Ferreira, L, Oliveira, VC, Ferreira, PH, Ji, F, Ning, F, Pang, Z, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Burt, SA, Klump, KL, Martin, NG, Medland, SE, Montgomery, GW, Kandler, C, McAdams, TA, Eley, TC, Gregory, AM, Saudino, KJ, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Tarnoki, AD, Tarnoki, DL, Haworth, CMA, Plomin, R, Öncel, SY, Aliev, F, Medda, E, Nisticò, L, Toccaceli, V, Craig, JM, Saffery, R, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Jeong, HU, Spector, T, Mangino, M, Lachance, G, Gatz, M, Butler, DA, Gao, W, Yu, C, Li, L, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJF, Cozen, W, Hwang, AE, Mack, TM, He, M, Ding, X, Silberg, JL, Maes, HH, Cutler, TL, Hopper, JL, Magnusson, PKE, Pedersen, NL, Dahl Aslan, AK, Baker, LA, Tuvblad, C, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Ullemar, V, Almqvist, C, Tan, Q, Zhang, D, Swan, GE, Krasnow, R, Jang, KL, Knafo-Noam, A, Mankuta, D, Abramson, L, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Tynelius, P, Rasmussen, F, Duncan, GE, Buchwald, D, Corley, RP, Huibregtse, BM, Nelson, TL, Whitfield, KE, Franz, CE, Kremen, WS, Lyons, MJ, Ooki, S, Brandt, I, Nilsen, TS, Harris, JR, Sung, J, Park, HA, Lee, J, Lee, SJ, Willemsen, G, Bartels, M, Van Beijsterveldt, CEM, Llewellyn, CH, Fisher, A, Rebato, E, Busjahn, A, Tomizawa, R, Inui, F, Watanabe, M, Honda, C, Sakai, N, Hur, YM, Sorensen, TIA, Boomsma, DI & Kaprio, J 2019, 'The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins', Twin Research and Human Genetics. https://doi.org/10.1017/thg.2019.35
Silventoinen, K. ; Jelenkovic, A. ; Yokoyama, Y. ; Sund, R. ; Sugawara, M. ; Tanaka, M. ; Matsumoto, S. ; Bogl, L. H. ; Freitas, D. L. ; Maia, J. A. ; Hjelmborg, J. V.B. ; Aaltonen, S. ; Piirtola, M. ; Latvala, A. ; Calais-Ferreira, L. ; Oliveira, V. C. ; Ferreira, P. H. ; Ji, F. ; Ning, F. ; Pang, Z. ; Ordoñana, J. R. ; Sánchez-Romera, J. F. ; Colodro-Conde, L. ; Burt, S. A. ; Klump, K. L. ; Martin, N. G. ; Medland, S. E. ; Montgomery, G. W. ; Kandler, C. ; McAdams, T. A. ; Eley, T. C. ; Gregory, A. M. ; Saudino, K. J. ; Dubois, L. ; Boivin, M. ; Brendgen, M. ; Dionne, G. ; Vitaro, F. ; Tarnoki, A. D. ; Tarnoki, D. L. ; Haworth, C. M.A. ; Plomin, R. ; Öncel, S. Y. ; Aliev, F. ; Medda, E. ; Nisticò, L. ; Toccaceli, V. ; Craig, J. M. ; Saffery, R. ; Siribaddana, S. H. ; Hotopf, M. ; Sumathipala, A. ; Rijsdijk, F. ; Jeong, H. U. ; Spector, T. ; Mangino, M. ; Lachance, G. ; Gatz, M. ; Butler, D. A. ; Gao, W. ; Yu, C. ; Li, L. ; Bayasgalan, G. ; Narandalai, D. ; Harden, K. P. ; Tucker-Drob, E. M. ; Christensen, K. ; Skytthe, A. ; Kyvik, K. O. ; Derom, C. A. ; Vlietinck, R. F. ; Loos, R. J.F. ; Cozen, W. ; Hwang, A. E. ; Mack, T. M. ; He, M. ; Ding, X. ; Silberg, J. L. ; Maes, H. H. ; Cutler, T. L. ; Hopper, J. L. ; Magnusson, P. K.E. ; Pedersen, N. L. ; Dahl Aslan, A. K. ; Baker, L. A. ; Tuvblad, C. ; Bjerregaard-Andersen, M. ; Beck-Nielsen, H. ; Sodemann, M. ; Ullemar, V. ; Almqvist, C. ; Tan, Q. ; Zhang, D. ; Swan, G. E. ; Krasnow, R. ; Jang, K. L. ; Knafo-Noam, A. ; Mankuta, D. ; Abramson, L. ; Lichtenstein, P. ; Krueger, R. F. ; McGue, M. ; Pahlen, S. ; Tynelius, P. ; Rasmussen, F. ; Duncan, G. E. ; Buchwald, D. ; Corley, R. P. ; Huibregtse, B. M. ; Nelson, T. L. ; Whitfield, K. E. ; Franz, C. E. ; Kremen, W. S. ; Lyons, M. J. ; Ooki, S. ; Brandt, I. ; Nilsen, T. S. ; Harris, J. R. ; Sung, J. ; Park, H. A. ; Lee, J. ; Lee, S. J. ; Willemsen, G. ; Bartels, M. ; Van Beijsterveldt, C. E.M. ; Llewellyn, C. H. ; Fisher, A. ; Rebato, E. ; Busjahn, A. ; Tomizawa, R. ; Inui, F. ; Watanabe, M. ; Honda, C. ; Sakai, N. ; Hur, Y. M. ; Sorensen, T. I.A. ; Boomsma, D. I. ; Kaprio, J. / The CODATwins Project : The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. In: Twin Research and Human Genetics. 2019.
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title = "The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins",
abstract = "The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.",
keywords = "BMI, Twins, birth size, education, height, heritability, international comparisons",
author = "K. Silventoinen and A. Jelenkovic and Y. Yokoyama and R. Sund and M. Sugawara and M. Tanaka and S. Matsumoto and Bogl, {L. H.} and Freitas, {D. L.} and Maia, {J. A.} and Hjelmborg, {J. V.B.} and S. Aaltonen and M. Piirtola and A. Latvala and L. Calais-Ferreira and Oliveira, {V. C.} and Ferreira, {P. H.} and F. Ji and F. Ning and Z. Pang and Ordo{\~n}ana, {J. R.} and S{\'a}nchez-Romera, {J. F.} and L. Colodro-Conde and Burt, {S. A.} and Klump, {K. L.} and Martin, {N. G.} and Medland, {S. E.} and Montgomery, {G. W.} and C. Kandler and McAdams, {T. A.} and Eley, {T. C.} and Gregory, {A. M.} and Saudino, {K. J.} and L. Dubois and M. Boivin and M. Brendgen and G. Dionne and F. Vitaro and Tarnoki, {A. D.} and Tarnoki, {D. L.} and Haworth, {C. M.A.} and R. Plomin and {\"O}ncel, {S. Y.} and F. Aliev and E. Medda and L. Nistic{\`o} and V. Toccaceli and Craig, {J. M.} and R. Saffery and Siribaddana, {S. H.} and M. Hotopf and A. Sumathipala and F. Rijsdijk and Jeong, {H. U.} and T. Spector and M. Mangino and G. Lachance and M. Gatz and Butler, {D. A.} and W. Gao and C. Yu and L. Li and G. Bayasgalan and D. Narandalai and Harden, {K. P.} and Tucker-Drob, {E. M.} and K. Christensen and A. Skytthe and Kyvik, {K. O.} and Derom, {C. A.} and Vlietinck, {R. F.} and Loos, {R. J.F.} and W. Cozen and Hwang, {A. E.} and Mack, {T. M.} and M. He and X. Ding and Silberg, {J. L.} and Maes, {H. H.} and Cutler, {T. L.} and Hopper, {J. L.} and Magnusson, {P. K.E.} and Pedersen, {N. L.} and {Dahl Aslan}, {A. K.} and Baker, {L. A.} and C. Tuvblad and M. Bjerregaard-Andersen and H. Beck-Nielsen and M. Sodemann and V. Ullemar and C. Almqvist and Q. Tan and D. Zhang and Swan, {G. E.} and R. Krasnow and Jang, {K. L.} and A. Knafo-Noam and D. Mankuta and L. Abramson and P. Lichtenstein and Krueger, {R. F.} and M. McGue and S. Pahlen and P. Tynelius and F. Rasmussen and Duncan, {G. E.} and D. Buchwald and Corley, {R. P.} and Huibregtse, {B. M.} and Nelson, {T. L.} and Whitfield, {K. E.} and Franz, {C. E.} and Kremen, {W. S.} and Lyons, {M. J.} and S. Ooki and I. Brandt and Nilsen, {T. S.} and Harris, {J. R.} and J. Sung and Park, {H. A.} and J. Lee and Lee, {S. J.} and G. Willemsen and M. Bartels and {Van Beijsterveldt}, {C. E.M.} and Llewellyn, {C. H.} and A. Fisher and E. Rebato and A. Busjahn and R. Tomizawa and F. Inui and M. Watanabe and C. Honda and N. Sakai and Hur, {Y. M.} and Sorensen, {T. I.A.} and Boomsma, {D. I.} and J. Kaprio",
year = "2019",
month = "1",
day = "1",
doi = "10.1017/thg.2019.35",
language = "English (US)",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",

}

TY - JOUR

T1 - The CODATwins Project

T2 - The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

AU - Silventoinen, K.

AU - Jelenkovic, A.

AU - Yokoyama, Y.

AU - Sund, R.

AU - Sugawara, M.

AU - Tanaka, M.

AU - Matsumoto, S.

AU - Bogl, L. H.

AU - Freitas, D. L.

AU - Maia, J. A.

AU - Hjelmborg, J. V.B.

AU - Aaltonen, S.

AU - Piirtola, M.

AU - Latvala, A.

AU - Calais-Ferreira, L.

AU - Oliveira, V. C.

AU - Ferreira, P. H.

AU - Ji, F.

AU - Ning, F.

AU - Pang, Z.

AU - Ordoñana, J. R.

AU - Sánchez-Romera, J. F.

AU - Colodro-Conde, L.

AU - Burt, S. A.

AU - Klump, K. L.

AU - Martin, N. G.

AU - Medland, S. E.

AU - Montgomery, G. W.

AU - Kandler, C.

AU - McAdams, T. A.

AU - Eley, T. C.

AU - Gregory, A. M.

AU - Saudino, K. J.

AU - Dubois, L.

AU - Boivin, M.

AU - Brendgen, M.

AU - Dionne, G.

AU - Vitaro, F.

AU - Tarnoki, A. D.

AU - Tarnoki, D. L.

AU - Haworth, C. M.A.

AU - Plomin, R.

AU - Öncel, S. Y.

AU - Aliev, F.

AU - Medda, E.

AU - Nisticò, L.

AU - Toccaceli, V.

AU - Craig, J. M.

AU - Saffery, R.

AU - Siribaddana, S. H.

AU - Hotopf, M.

AU - Sumathipala, A.

AU - Rijsdijk, F.

AU - Jeong, H. U.

AU - Spector, T.

AU - Mangino, M.

AU - Lachance, G.

AU - Gatz, M.

AU - Butler, D. A.

AU - Gao, W.

AU - Yu, C.

AU - Li, L.

AU - Bayasgalan, G.

AU - Narandalai, D.

AU - Harden, K. P.

AU - Tucker-Drob, E. M.

AU - Christensen, K.

AU - Skytthe, A.

AU - Kyvik, K. O.

AU - Derom, C. A.

AU - Vlietinck, R. F.

AU - Loos, R. J.F.

AU - Cozen, W.

AU - Hwang, A. E.

AU - Mack, T. M.

AU - He, M.

AU - Ding, X.

AU - Silberg, J. L.

AU - Maes, H. H.

AU - Cutler, T. L.

AU - Hopper, J. L.

AU - Magnusson, P. K.E.

AU - Pedersen, N. L.

AU - Dahl Aslan, A. K.

AU - Baker, L. A.

AU - Tuvblad, C.

AU - Bjerregaard-Andersen, M.

AU - Beck-Nielsen, H.

AU - Sodemann, M.

AU - Ullemar, V.

AU - Almqvist, C.

AU - Tan, Q.

AU - Zhang, D.

AU - Swan, G. E.

AU - Krasnow, R.

AU - Jang, K. L.

AU - Knafo-Noam, A.

AU - Mankuta, D.

AU - Abramson, L.

AU - Lichtenstein, P.

AU - Krueger, R. F.

AU - McGue, M.

AU - Pahlen, S.

AU - Tynelius, P.

AU - Rasmussen, F.

AU - Duncan, G. E.

AU - Buchwald, D.

AU - Corley, R. P.

AU - Huibregtse, B. M.

AU - Nelson, T. L.

AU - Whitfield, K. E.

AU - Franz, C. E.

AU - Kremen, W. S.

AU - Lyons, M. J.

AU - Ooki, S.

AU - Brandt, I.

AU - Nilsen, T. S.

AU - Harris, J. R.

AU - Sung, J.

AU - Park, H. A.

AU - Lee, J.

AU - Lee, S. J.

AU - Willemsen, G.

AU - Bartels, M.

AU - Van Beijsterveldt, C. E.M.

AU - Llewellyn, C. H.

AU - Fisher, A.

AU - Rebato, E.

AU - Busjahn, A.

AU - Tomizawa, R.

AU - Inui, F.

AU - Watanabe, M.

AU - Honda, C.

AU - Sakai, N.

AU - Hur, Y. M.

AU - Sorensen, T. I.A.

AU - Boomsma, D. I.

AU - Kaprio, J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

AB - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

KW - BMI

KW - Twins

KW - birth size

KW - education

KW - height

KW - heritability

KW - international comparisons

UR - http://www.scopus.com/inward/record.url?scp=85070056867&partnerID=8YFLogxK

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U2 - 10.1017/thg.2019.35

DO - 10.1017/thg.2019.35

M3 - Article

C2 - 31364586

AN - SCOPUS:85070056867

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

ER -