The cnidarian and the canon: The role of Wnt/β-catenin signaling in the evolution of metazoan embryos

Alex Primus, Gary Freeman

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

In a recent publication, Wikramanayake and colleagues have implicated the canonical Wnt/β-catenin signaling pathway as a mediator of axial polarity and germ-layer specification in embryos of the cnidarian Nematostella. In this anthozoan, β-catenin is localized in nuclei of blastomeres in one region of the 16- to 32-cell embryo whose descendants subsequently form the entoderm of the embryo. They claim that the pattern of nuclear localization is significant for two reasons: (1) when nuclear localization of β-catenin was inhibited, gastrulation does not occur, and (2) when localization of β-catenin took place in all cells of the pregastrula embryo, the number of entodermal cells increases. Since the Wnt/β-catenin signaling pathway also plays a role in establishing axial polarity and specifying endoderm and mesoderm in a number of bilaterians, Wikramanayake et al. imply that this developmental mechanism is an evolutionary inheritance from a redially symmetrical ancestor. Some of the gaps in the current evidence, which must be filled to evaluate their interpretation, are discussed.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalBioEssays
Volume26
Issue number5
DOIs
StatePublished - May 1 2004

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Cnidaria
Catenins
embryo (animal)
Embryonic Structures
Wnt Signaling Pathway
blastomeres
cells
Germ Layers
Blastomeres
Gastrulation
Endoderm
Mesoderm
inheritance (genetics)
ancestry
Cell Count
Specifications

Cite this

The cnidarian and the canon : The role of Wnt/β-catenin signaling in the evolution of metazoan embryos. / Primus, Alex; Freeman, Gary.

In: BioEssays, Vol. 26, No. 5, 01.05.2004, p. 474-478.

Research output: Contribution to journalReview article

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