The childhood asthma management program (CAMP): Design, rationale, and methods

Gail G. Shapiro, Thomas R. DuHamel, Timothy G. Wighton, Tamara Chinn, C. Warren Bierman, Clifton T. Furukawa, Leonard C. Altman, Frank S. Virant, Paul V. Williams, Dominick A. Minotti, Michael S. Kennedy, Jonathan W. Becker, Chris Reagan, Heather Eliassen, Dan Crawford, Babi Hammond, Grace Strodtbeck, Marian Sharpe, Scott Weiss, Dirk GreinederWalter Torda, Martha Tata, Peter Barrant, Anthony DeFilippo, Mary Grace, Stephanie Haynes, Margaret Higham, Susan Kelleher, Jay Koslof, Nancy Madden, Dana Mandel, Agnes Martinez, Jean McAuliffe, Paola Pacella, Paula Parks, Anne Plunkett, Kay Seligsohn, June Traylor, Melissa Van Horn, Janice Ware, Carolyn Wells, Ann Whitman, Joe Reisman, Ian MacLusky, Henry Levison, Anita Hall, Yola Benedet, Jennifer Chay, Michelle Collinson, John Connett, Childhood Asthma Management Program Research Group

Research output: Contribution to journalArticle

281 Scopus citations

Abstract

The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.

Original languageEnglish (US)
Pages (from-to)91-120
Number of pages30
JournalControlled clinical trials
Volume20
Issue number1
DOIs
StatePublished - Feb 1999

Keywords

  • Albuterol
  • Allergens
  • Anti-inflammatory agents
  • Atopy
  • Bronchial provocation test
  • Bronchodilator agents
  • Budesonide
  • Childhood asthma
  • Clinical trials
  • Environmental exposure
  • Glucocorticoids
  • Growth
  • Inhaled bronchodilator
  • Nedocromil
  • Psychological test
  • Spirometry

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    Shapiro, G. G., DuHamel, T. R., Wighton, T. G., Chinn, T., Bierman, C. W., Furukawa, C. T., Altman, L. C., Virant, F. S., Williams, P. V., Minotti, D. A., Kennedy, M. S., Becker, J. W., Reagan, C., Eliassen, H., Crawford, D., Hammond, B., Strodtbeck, G., Sharpe, M., Weiss, S., ... Childhood Asthma Management Program Research Group (1999). The childhood asthma management program (CAMP): Design, rationale, and methods. Controlled clinical trials, 20(1), 91-120. https://doi.org/10.1016/S0197-2456(98)00044-0