The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif

Nathan J Schuld, Jeffrey S. Vervacke, Ellen L. Lorimer, Nathan C. Simon, Andrew D. Hauser, Joseph T. Barbieri, Mark D Distefano, Carol L. Williams

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: SmgGDS-607 and SmgGDS-558 regulate GTPase movement through the prenylation pathway. Results: The specificity of SmgGDS for GTPases depends on the GTPase CAAX sequence and the cellular context. Conclusion: SmgGDS-607 binds to nonprenylated GTPases that end in a leucine and enter the geranylgeranylation pathway. Significance: The identification of SmgGDS-607 as a novel CAAX-binding protein will accelerate the development of more effective cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)6862-6876
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
StatePublished - Mar 7 2014

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Prenylation
Monomeric GTP-Binding Proteins
GTP Phosphohydrolases
Amino Acids
Proteins
Leucine
Carrier Proteins
Neoplasms

Cite this

Schuld, N. J., Vervacke, J. S., Lorimer, E. L., Simon, N. C., Hauser, A. D., Barbieri, J. T., ... Williams, C. L. (2014). The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. Journal of Biological Chemistry, 289(10), 6862-6876. https://doi.org/10.1074/jbc.M113.527192

The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. / Schuld, Nathan J; Vervacke, Jeffrey S.; Lorimer, Ellen L.; Simon, Nathan C.; Hauser, Andrew D.; Barbieri, Joseph T.; Distefano, Mark D; Williams, Carol L.

In: Journal of Biological Chemistry, Vol. 289, No. 10, 07.03.2014, p. 6862-6876.

Research output: Contribution to journalArticle

Schuld, Nathan J ; Vervacke, Jeffrey S. ; Lorimer, Ellen L. ; Simon, Nathan C. ; Hauser, Andrew D. ; Barbieri, Joseph T. ; Distefano, Mark D ; Williams, Carol L. / The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 10. pp. 6862-6876.
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