The challenges of treating aspergillus abdominal aneurysm after hematopoietic cell transplant: Rapid voriconazole metabolizer

Justin A. Wasko, Celalettin Ustun, Mark Birkenbach, Rumi Faizer, Jaime S Green

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Mycotic aneurysms are a fatal manifestation of disseminated fungal infections in immunocompromised hosts. We present a patient with an Aspergillus mycotic aneurysm after hematopoietic cell transplant. Due to CYP2C19 rapid metabolizer phenotype (*1/*17), therapeutic levels of voriconazole were unobtainable. Successful therapy was achieved with posaconazole salvage therapy and early, aggressive surgery. This case demonstrates the consequences of voriconazole rapid metabolism and the potential impact of genetic variants.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalJournal of Oncology Pharmacy Practice
Volume25
Issue number3
DOIs
StatePublished - Apr 1 2019

Keywords

  • Aspergillus
  • CYP2C19
  • posaconazole
  • rapid metabolism
  • voriconazole

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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