This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.
Bibliographical noteFunding Information:
This work was supported by DA013680, Core funding NS062158, NS048944, NS077661 and NSF IOS-1146016.
- Estrogen receptor
- Hormone therapy
- Motor control
- Purkinje neuron