The cerebellum as a target for estrogen action

Valerie L. Hedges; Timothy J. Ebner; Robert L. Meisel; Paul G. Mermelstein

doi:10.1016/j.yfrne.2012.08.005

The cerebellum as a target for estrogen action

Valerie L. Hedges, Timothy J. Ebner, Robert L. Meisel, Paul G. Mermelstein

Neuroscience

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

Original language	English (US)
Pages (from-to)	403-411
Number of pages	9
Journal	Frontiers in Neuroendocrinology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.yfrne.2012.08.005
State	Published - Oct 2012

Bibliographical note

Funding Information:
This work was supported by DA013680, Core funding NS062158, NS048944, NS077661 and NSF IOS-1146016.

Keywords

Alcohol
Ataxia
Estradiol
Estrogen receptor
Glutamate
Hormone therapy
Motor control
Neuroprotection
Purkinje neuron

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10.1016/j.yfrne.2012.08.005

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title = "The cerebellum as a target for estrogen action",

abstract = "This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.",

keywords = "Alcohol, Ataxia, Estradiol, Estrogen receptor, Glutamate, Hormone therapy, Motor control, Neuroprotection, Purkinje neuron",

author = "Hedges, {Valerie L.} and Ebner, {Timothy J.} and Meisel, {Robert L.} and Mermelstein, {Paul G.}",

note = "Funding Information: This work was supported by DA013680, Core funding NS062158, NS048944, NS077661 and NSF IOS-1146016.",

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AU - Hedges, Valerie L.

AU - Ebner, Timothy J.

AU - Meisel, Robert L.

AU - Mermelstein, Paul G.

N1 - Funding Information: This work was supported by DA013680, Core funding NS062158, NS048944, NS077661 and NSF IOS-1146016.

PY - 2012/10

Y1 - 2012/10

N2 - This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

AB - This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

KW - Alcohol

KW - Ataxia

KW - Estradiol

KW - Estrogen receptor

KW - Glutamate

KW - Hormone therapy

KW - Motor control

KW - Neuroprotection

KW - Purkinje neuron

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DO - 10.1016/j.yfrne.2012.08.005

M3 - Review article

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SN - 0091-3022

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JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

IS - 4

ER -

The cerebellum as a target for estrogen action

Abstract

Bibliographical note

Keywords

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