The cell biology of autophagy in metazoans: A developing story

Alicia Meléndez, Thomas P. Neufeld

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

The cell biological phenomenon of autophagy (or 'self-eating') has attracted increasing attention in recent years. In this review, we first address the cell biological functions of autophagy, and then discuss recent insights into the role of autophagy in animal development, particularly in C. elegans, Drosophila and mouse. Work in these and other model systems has also provided evidence for the involvement of autophagy in disease processes, such as neurodegeneration, tumorigenesis, pathogenic infection and aging. Insights gained from investigating the functions of autophagy in normal development should increase our understanding of its roles in human disease and its potential as a target for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)2347-2360
Number of pages14
JournalDevelopment
Volume135
Issue number14
DOIs
StatePublished - Aug 2008

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