The immunological hallmarks of sepsis include th inflammation-mediated cytokine storm, apoptosis-drive lymphopenia, and prolonged immunoparalysis. Althoug early clinical efforts were focused on increasing the sur vival of patients through the first phase, studies are no shifting attention to the long-term effects of sepsis o immune fitness in survivors. In particular, the most perti nent task is deciphering how the immune system become suppressed, leading to increased incidence of secondar infections. In this review, we introduce the contributio of numerical changes and functional reprogrammin within innate (NK cells, dendritic cells) and adaptiv (T cells, B cells) immune cells on the chronic immun dysregulation in the septic murine and human host. W briefly discuss how prior immunological experience i murine models impacts sepsis severity, immune dysfunc tion, and clinical relevance. Finally, we dive into ho comorbidities, specifically autoimmunity and cancer, ca influence host susceptibility to sepsis and the associate immune dysfunction.
Bibliographical noteFunding Information:
AI114543 (to V.P.B.); and a Veterans Administration Merit Review Award I01BX001324 (to T.S.G.). V.P.B. is a University of Iowa Distinguished Scholar. T.S.G. is the recipient of a Research Career Scientist award (IK6BX006192) and a U.S. Department of Veterans Affairs Merit Review Award I01BX001324 (to T.S.G.).
This work was supported by the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Grant T32AI007511 (to E.E.S.); National Institute of General Medical Sciences, National Institutes of Health Grants GM134880 (to V.P.B.) and R35GM140881 (to T.S.G.); National Institute of Allergy and Infectious Diseases, National Institutes of Health Grant
Copyright © 2023 by The American Association of Immunologists, Inc.
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.