The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

John J. Lima; Janet T. Holbrook; Jianwei Wang; James E. Sylvester; Kathryn V. Blake; Malcolm N. Blumenthal; Mario Castro; Nicholas Hanania; Robert Wise

doi:10.1080/02770900600566611

The C523A β₂ adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

John J. Lima
, Janet T. Holbrook
, Jianwei Wang
, James E. Sylvester
, Kathryn V. Blake
, Malcolm N. Blumenthal
, Mario Castro
, Nicholas Hanania
, Robert Wise

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Our goal was to explore associations between β₂ adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

Original language	English (US)
Pages (from-to)	185-191
Number of pages	7
Journal	Journal of Asthma
Volume	43
Issue number	3
DOIs	https://doi.org/10.1080/02770900600566611
State	Published - 2006

Bibliographical note

Funding Information:
Supported by the American Lung Association, Nemours Research Foundation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asthma severity
Polymorphisms
Race
β adrenergic receptor

Publisher link

10.1080/02770900600566611

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Cite this

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title = "The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans",

abstract = "Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40\%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.",

keywords = "Asthma severity, Polymorphisms, Race, β adrenergic receptor",

author = "Lima, \{John J.\} and Holbrook, \{Janet T.\} and Jianwei Wang and Sylvester, \{James E.\} and Blake, \{Kathryn V.\} and Blumenthal, \{Malcolm N.\} and Mario Castro and Nicholas Hanania and Robert Wise",

note = "Funding Information: Supported by the American Lung Association, Nemours Research Foundation.",

year = "2006",

doi = "10.1080/02770900600566611",

language = "English (US)",

volume = "43",

pages = "185--191",

journal = "Journal of Asthma",

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T1 - The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

AU - Lima, John J.

AU - Holbrook, Janet T.

AU - Wang, Jianwei

AU - Sylvester, James E.

AU - Blake, Kathryn V.

AU - Blumenthal, Malcolm N.

AU - Castro, Mario

AU - Hanania, Nicholas

AU - Wise, Robert

N1 - Funding Information: Supported by the American Lung Association, Nemours Research Foundation.

PY - 2006

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N2 - Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

AB - Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

KW - Asthma severity

KW - Polymorphisms

KW - Race

KW - β adrenergic receptor

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