The c-fos gene and early-onset familial Alzheimer's disease

Lori L.C. Bonnycastle; Chang En Yu; Ellen M. Wijsman; Harry T. Orr; David Patterson; Kevin P. Clancy; Katrina A.B. Goddard; M. Elisa Alonso; Ellen Nemens; June A. White; Leonard L. Heston; George M. Martin; Thomas D. Bird; Gerard D. Schellenberg

doi:10.1016/0304-3940(93)90910-D

The c-fos gene and early-onset familial Alzheimer's disease

Lori L.C. Bonnycastle, Chang En Yu, Ellen M. Wijsman, Harry T. Orr, David Patterson, Kevin P. Clancy, Katrina A.B. Goddard, M. Elisa Alonso, Ellen Nemens, June A. White, Leonard L. Heston, George M. Martin, Thomas D. Bird, Gerard D. Schellenberg

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome (YAC) clone was identified which contains FOS. This YAC also contains the short-tandem repeat polymorphic (STRP) locus D14S76, placing FOS in the FAD region between D14S53 and D14S43. No recombinants were observed between D14S76 and FAD, and a maximum positive LOD score of 7.20 at a recombination fraction of 0.001 was observed for linkage of this marker to FAD. DNA sequence analysis was used to examine FOS in two affected subjects from an FAD family in which the chromosome 14 FAD locus is clearly responsible for the disease. The coding regions and parts of the 5′ and 3′ untranslated sequences of FOS were sequenced; no FAD-related mutations were observed. This work suggests that the FOS gene is not the chromosome 14 FAD locus although we cannot exclude the possibility that a mutation in an as yet unknown regulatory region is responsible for the disease. A new polymorphism was detected in the third intron of the gene.

Original language	English (US)
Pages (from-to)	33-36
Number of pages	4
Journal	Neuroscience Letters
Volume	160
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(93)90910-D
State	Published - Sep 17 1993

Bibliographical note

Funding Information:
Supported by NIA Grants AG05136 (Alzheimer's DiseaseR esearchC enterat the Universityo f Washington) and AG00029 (D. Pattersona nd K.P. Clancey),a nd NIMH Grant R01MH 43240 (H.T. Orr, J.A. White and L.L. Heston). Also supportedb y GM 15253 Veterans AdministratioRne searchF unds(T.D. Bird), the American Health AssistanceF oundation(T .D. Bird, G.D. Sch-ellenbergJ,R K and SMP) and the Alzheimer'sA ssocia-tion (D. Patterson)W. e thank S. O'dahl, L. AndersonE, . Loomis and S. Ito for technicalh elp, and A.D. Roses and the KatheleenB ryantA lzheimer'Ds iseaseR esearch Center provided some of the cell lines for family LH (603). Informedc onsentw as obtainedfr om each subject or next-of-kinw ith approvalo f the Universityo f Washington Human SubjectsR eviewCommittee.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Chromosome 14
FOS
Familial Alzheimer's disease
Linkage analysis
Sequence analysis
c-fos Gene

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title = "The c-fos gene and early-onset familial Alzheimer's disease",

abstract = "A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome (YAC) clone was identified which contains FOS. This YAC also contains the short-tandem repeat polymorphic (STRP) locus D14S76, placing FOS in the FAD region between D14S53 and D14S43. No recombinants were observed between D14S76 and FAD, and a maximum positive LOD score of 7.20 at a recombination fraction of 0.001 was observed for linkage of this marker to FAD. DNA sequence analysis was used to examine FOS in two affected subjects from an FAD family in which the chromosome 14 FAD locus is clearly responsible for the disease. The coding regions and parts of the 5′ and 3′ untranslated sequences of FOS were sequenced; no FAD-related mutations were observed. This work suggests that the FOS gene is not the chromosome 14 FAD locus although we cannot exclude the possibility that a mutation in an as yet unknown regulatory region is responsible for the disease. A new polymorphism was detected in the third intron of the gene.",

keywords = "Chromosome 14, FOS, Familial Alzheimer's disease, Linkage analysis, Sequence analysis, c-fos Gene",

author = "Bonnycastle, {Lori L.C.} and Yu, {Chang En} and Wijsman, {Ellen M.} and Orr, {Harry T.} and David Patterson and Clancy, {Kevin P.} and Goddard, {Katrina A.B.} and Alonso, {M. Elisa} and Ellen Nemens and White, {June A.} and Heston, {Leonard L.} and Martin, {George M.} and Bird, {Thomas D.} and Schellenberg, {Gerard D.}",

note = "Funding Information: Supported by NIA Grants AG05136 (Alzheimer's DiseaseR esearchC enterat the Universityo f Washington) and AG00029 (D. Pattersona nd K.P. Clancey),a nd NIMH Grant R01MH 43240 (H.T. Orr, J.A. White and L.L. Heston). Also supportedb y GM 15253 Veterans AdministratioRne searchF unds(T.D. Bird), the American Health AssistanceF oundation(T .D. Bird, G.D. Sch-ellenbergJ,R K and SMP) and the Alzheimer'sA ssocia-tion (D. Patterson)W. e thank S. O'dahl, L. AndersonE, . Loomis and S. Ito for technicalh elp, and A.D. Roses and the KatheleenB ryantA lzheimer'Ds iseaseR esearch Center provided some of the cell lines for family LH (603). Informedc onsentw as obtainedfr om each subject or next-of-kinw ith approvalo f the Universityo f Washington Human SubjectsR eviewCommittee. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1993",

month = sep,

day = "17",

doi = "10.1016/0304-3940(93)90910-D",

language = "English (US)",

volume = "160",

pages = "33--36",

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T1 - The c-fos gene and early-onset familial Alzheimer's disease

AU - Bonnycastle, Lori L.C.

AU - Yu, Chang En

AU - Wijsman, Ellen M.

AU - Orr, Harry T.

AU - Patterson, David

AU - Clancy, Kevin P.

AU - Goddard, Katrina A.B.

AU - Alonso, M. Elisa

AU - Nemens, Ellen

AU - White, June A.

AU - Heston, Leonard L.

AU - Martin, George M.

AU - Bird, Thomas D.

AU - Schellenberg, Gerard D.

N1 - Funding Information: Supported by NIA Grants AG05136 (Alzheimer's DiseaseR esearchC enterat the Universityo f Washington) and AG00029 (D. Pattersona nd K.P. Clancey),a nd NIMH Grant R01MH 43240 (H.T. Orr, J.A. White and L.L. Heston). Also supportedb y GM 15253 Veterans AdministratioRne searchF unds(T.D. Bird), the American Health AssistanceF oundation(T .D. Bird, G.D. Sch-ellenbergJ,R K and SMP) and the Alzheimer'sA ssocia-tion (D. Patterson)W. e thank S. O'dahl, L. AndersonE, . Loomis and S. Ito for technicalh elp, and A.D. Roses and the KatheleenB ryantA lzheimer'Ds iseaseR esearch Center provided some of the cell lines for family LH (603). Informedc onsentw as obtainedfr om each subject or next-of-kinw ith approvalo f the Universityo f Washington Human SubjectsR eviewCommittee. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1993/9/17

Y1 - 1993/9/17

N2 - A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome (YAC) clone was identified which contains FOS. This YAC also contains the short-tandem repeat polymorphic (STRP) locus D14S76, placing FOS in the FAD region between D14S53 and D14S43. No recombinants were observed between D14S76 and FAD, and a maximum positive LOD score of 7.20 at a recombination fraction of 0.001 was observed for linkage of this marker to FAD. DNA sequence analysis was used to examine FOS in two affected subjects from an FAD family in which the chromosome 14 FAD locus is clearly responsible for the disease. The coding regions and parts of the 5′ and 3′ untranslated sequences of FOS were sequenced; no FAD-related mutations were observed. This work suggests that the FOS gene is not the chromosome 14 FAD locus although we cannot exclude the possibility that a mutation in an as yet unknown regulatory region is responsible for the disease. A new polymorphism was detected in the third intron of the gene.

AB - A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome (YAC) clone was identified which contains FOS. This YAC also contains the short-tandem repeat polymorphic (STRP) locus D14S76, placing FOS in the FAD region between D14S53 and D14S43. No recombinants were observed between D14S76 and FAD, and a maximum positive LOD score of 7.20 at a recombination fraction of 0.001 was observed for linkage of this marker to FAD. DNA sequence analysis was used to examine FOS in two affected subjects from an FAD family in which the chromosome 14 FAD locus is clearly responsible for the disease. The coding regions and parts of the 5′ and 3′ untranslated sequences of FOS were sequenced; no FAD-related mutations were observed. This work suggests that the FOS gene is not the chromosome 14 FAD locus although we cannot exclude the possibility that a mutation in an as yet unknown regulatory region is responsible for the disease. A new polymorphism was detected in the third intron of the gene.

KW - Chromosome 14

KW - FOS

KW - Familial Alzheimer's disease

KW - Linkage analysis

KW - Sequence analysis

KW - c-fos Gene

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U2 - 10.1016/0304-3940(93)90910-D

DO - 10.1016/0304-3940(93)90910-D

M3 - Article

C2 - 8247328

AN - SCOPUS:0027484718

SN - 0304-3940

VL - 160

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EP - 36

JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

The c-fos gene and early-onset familial Alzheimer's disease

Abstract

Bibliographical note

Keywords

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