Background: The supply of blood in many low- and middle-income nations in Sub-Saharan Africa (SSA) does not meet the patient care needs. Lack and delay of blood transfusion cause harm to patients and slow the rate of progress in other parts of the health system. Recognizing the power of implementation science, the BLOODSAFE Program was initiated which supports three SSA research study teams and one data coordinating center (DCC) with the goal to improve access to safe blood transfusion in SSA. Study Design and Methods: The study team in Ghana is focusing on studying and decreasing iron deficiency in blood donors and evaluating social engagement of blood donors through different approaches. The study team in Kenya is building a “vein to vein” workflow model to elucidate and devise strategies to overcome barriers to blood donation and improve infrastructural components of blood product production and use. The Malawi team is studying the infectious disease ramifications of blood donation as well as blood donor retention strategies aimed at blood donors who commence their donation career in secondary schools. Results and Discussion: Together the project teams and the DCC work as a consortium to support each other through a shared study protocol that will study donor motivations, outcomes, and adverse events across all three countries. The BLOODSAFE Program has the potential to lead to generalizable improvement approaches for increasing access to safe blood in SSA as well as mentoring and building the research capacity and careers of many investigators.
Bibliographical noteFunding Information:
At the National Institutes of Health (NIH), research on blood availability and transfusion safety is supported by the National Heart, Lung, and Blood Institute (NHLBI). To identify key research priorities for improving global blood availability and transfusion safety, NHLBI's Division of Blood Diseases and Resources and Center for Translation Research and Implementation Science convened a workshop in April, 2017 on Research to Address Gaps in International Blood Availability & Transfusion Safety: Challenges & Opportunities. The workshop's working groups were comprised of global experts in transfusion medicine and implementation research from different regions. Together, they discussed challenges and opportunities in international blood availability and transfusion safety and identified key scientific priorities and research strategies for their region. 8 8,9
The BLOODSAFE program is supported by research grants from the National Heart, Lung, and Blood Institute (NHLBI grants UG3HL151595, UG3HL151599, UG3HL152189, and U24HL151541). The authors thank members of the NHLBI Observational Study Monitoring Board (OSMB)/Data and Safety Monitoring Board (DSMB) for their review of the protocols and study progress: E.L. Murphy (Chair), E. Bukusi, H.A. Hume, O. Ogedegbe, S. Person, and A.E. Mast (ad hoc).
© 2022 AABB.
- Sub-Saharan Africa
- blood donation
- blood transfusion
- implementation science