The Biological Activity of Di-α-Tocopherone

D. J. Lee; H. H. Draper; J. G. Bergan; A. Saari Csallany

doi:10.3181/00379727-113-28330

The Biological Activity of Di-α-Tocopherone

D. J. Lee, H. H. Draper, J. G. Bergan, A. Saari Csallany

Food Science and Nutrition

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Abstract

Di-α-tocopherone, a recently characterized metabolite of α-tocopherol isolated from animal tissues, was tested for biological activity with respect to resorption-gestation in Vit. E-deficient rats, nutritional muscular dystrophy in rabbits and hereditary muscular dystrophy in mice. The results indicate that this metabolite has less than 5% of the Vit. E activity of α-tocopherol and that it possesses no therapeutic value in treatment of the congenital myopathy. Its probable role in metabolism is that of a terminal oxidation product rather than an active form of Vit. E.

Original language	English (US)
Pages (from-to)	242-245
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	113
Issue number	1
DOIs	https://doi.org/10.3181/00379727-113-28330
State	Published - May 1963

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Supported by a grant from National Science Foundation.

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abstract = "Di-α-tocopherone, a recently characterized metabolite of α-tocopherol isolated from animal tissues, was tested for biological activity with respect to resorption-gestation in Vit. E-deficient rats, nutritional muscular dystrophy in rabbits and hereditary muscular dystrophy in mice. The results indicate that this metabolite has less than 5% of the Vit. E activity of α-tocopherol and that it possesses no therapeutic value in treatment of the congenital myopathy. Its probable role in metabolism is that of a terminal oxidation product rather than an active form of Vit. E.",

author = "Lee, {D. J.} and Draper, {H. H.} and Bergan, {J. G.} and Csallany, {A. Saari}",

note = "Funding Information: Supported by a grant from National Science Foundation.",

year = "1963",

month = may,

doi = "10.3181/00379727-113-28330",

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AU - Draper, H. H.

AU - Bergan, J. G.

AU - Csallany, A. Saari

N1 - Funding Information: Supported by a grant from National Science Foundation.

PY - 1963/5

Y1 - 1963/5

N2 - Di-α-tocopherone, a recently characterized metabolite of α-tocopherol isolated from animal tissues, was tested for biological activity with respect to resorption-gestation in Vit. E-deficient rats, nutritional muscular dystrophy in rabbits and hereditary muscular dystrophy in mice. The results indicate that this metabolite has less than 5% of the Vit. E activity of α-tocopherol and that it possesses no therapeutic value in treatment of the congenital myopathy. Its probable role in metabolism is that of a terminal oxidation product rather than an active form of Vit. E.

AB - Di-α-tocopherone, a recently characterized metabolite of α-tocopherol isolated from animal tissues, was tested for biological activity with respect to resorption-gestation in Vit. E-deficient rats, nutritional muscular dystrophy in rabbits and hereditary muscular dystrophy in mice. The results indicate that this metabolite has less than 5% of the Vit. E activity of α-tocopherol and that it possesses no therapeutic value in treatment of the congenital myopathy. Its probable role in metabolism is that of a terminal oxidation product rather than an active form of Vit. E.

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The Biological Activity of Di-α-Tocopherone

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