The Biological Activity of Di-α-Tocopherone

D. J. Lee, H. H. Draper, J. G. Bergan, A. Saari Csallany

Research output: Contribution to journalArticlepeer-review


Di-α-tocopherone, a recently characterized metabolite of α-tocopherol isolated from animal tissues, was tested for biological activity with respect to resorption-gestation in Vit. E-deficient rats, nutritional muscular dystrophy in rabbits and hereditary muscular dystrophy in mice. The results indicate that this metabolite has less than 5% of the Vit. E activity of α-tocopherol and that it possesses no therapeutic value in treatment of the congenital myopathy. Its probable role in metabolism is that of a terminal oxidation product rather than an active form of Vit. E.

Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - May 1963

Bibliographical note

Funding Information:
Supported by a grant from National Science Foundation.


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