The bihormonal bionic pancreas improves glycemic control in individuals with hyperinsulinism and postpancreatectomy diabetes: A pilot study

Arpana Rayannavar, Lauren M. Mitteer, Courtney A. Balliro, Firas H. El-Khatib, Katherine L. Lord, Colin P. Hawkes, Lance S. Ballester, Edward R. Damiano, Steven J. Russell, Diva D. De Leon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

OBJECTIVE To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC). RESEARCH DESIGN AND METHODS Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L. RESULTS Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P 5 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P 5 0.11). CONCLUSIONS Relative to UC, the BHBP resulted in comparable glycemic control in our population.

Original languageEnglish (US)
Pages (from-to)2582-2585
Number of pages4
JournalDiabetes care
Volume44
Issue number11
DOIs
StatePublished - Nov 1 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the American Diabetes Association.

PubMed: MeSH publication types

  • Journal Article
  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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