The Baroreflex in Hypertension

Genaro Fernandez, Junsoo Alex Lee, Lynn C. Liu, John P. Gassler

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Hypertension is a complex syndrome that increases the risk of developing other medical comorbidities and interacts with other medical conditions to increase the risk of target end-organ damage such as cardiovascular disease, stroke, and renal disease. Hypertension remains under-recognized and poorly controlled in the USA and worldwide. In some patients, hypertension is resistant to optimal medical therapy. Over the last few decades, there has been an increasing understanding of the role of the sympathetic nervous system in the development and maintenance of hypertension. This update reviews the physiology and role of the sympathetic nervous system in hypertension and pharmacological and interventional treatments directed at nervous system involvement in secondary hypertension.

Original languageEnglish (US)
JournalCurrent Hypertension Reports
Volume17
Issue number4
DOIs
StatePublished - Jan 1 2015

Keywords

  • Baroreflex
  • Baroreflex activation therapy
  • Renal denervation therapy
  • Renal sympathetic innervation
  • Resistant hypertension
  • Rheos
  • Secondary hypertension
  • Sympathetic nervous system

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