The association of socioeconomic status with receipt of neoadjuvant chemotherapy

Joan M. Neuner, Amanda Kong, Ann Blaes, Danielle Riley, Elizabeth Chrischilles, Alicia Smallwood, Ingrid Lizarraga, Mary Schroeder

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: There are advantages to neoadjuvant chemotherapy in operable breast cancer, particularly for those with higher-risk cancers, but little is known about factors that are associated with the use of neoadjuvant chemotherapy outside of clinical trials. We examined whether use of neoadjuvant chemotherapy instead of adjuvant chemotherapy varies by nonclinical factors such as patient socioeconomic status or rural residence. Methods: Women diagnosed with breast cancer in 2013–2014 at eight medical institutions were surveyed by mail regarding their experiences with breast cancer treatment, and this information was linked to hospital-based cancer registries. We examined the use of neoadjuvant chemotherapy among women with histologically confirmed invasive stage I–III breast cancer and used regression models to examine the association of socioeconomic status with chemotherapy timing. We also explored potential mechanisms for those differences. Results: Over 29% of the chemotherapy sample overall received neoadjuvant chemotherapy. Neoadjuvant receipt was lower for those with income < $100,000 (AOR 0.56, 95% CI 0.2–0.9) even with adjustment for other demographics, stage, and biomarker status, and findings for education and a variable for both lowest education and income < $100,000 were similar. Rural/urban residence was not associated with neoadjuvant receipt. Differences by income in perceptions of the importance of neoadjuvant chemotherapy advantages and disadvantages did not appear to explain the differences in use by income. Conclusions: In a multicenter sample of breast cancer patients, lower income was strongly associated with less receipt of neoadjuvant chemotherapy. Since patients with lower socioeconomic status are more likely to present with later-stage disease, this pattern has the potential to contribute to breast cancer outcome disparities.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalBreast Cancer Research and Treatment
Volume173
Issue number1
DOIs
StatePublished - Jan 15 2019

Bibliographical note

Funding Information:
Funding The authors gratefully acknowledge funding by the National Institute on Minority Health and Health Disparities under Grant R01 MD010728 and from the PCORI research contract CDRN-1306-04631.

Funding Information:
The authors would like to acknowledge the Share Thoughts on Breast Cancer patient advocates who helped develop the study question and questionnaire: Cheryl Jernigan, Jody Rock, and Laurel Hoeth; the study site coordinators and project managers who conducted the study mailings: Teresa Bosler, Michele Coady, Mack Dressler, Sarah Esmond, Bret Gardner, Brian Gryzlak, Julie McGregor, Deb Multerer, Char Napurski, Nick Rudzianski, Sabrina Uppal, Xiao Zhang, and Brittany Zschoche; investigators overseeing data collection: Ann Berger, PhD; Anne Blaes, MD; Elizabeth Chrischilles, PhD; Lindsay Cowell, PhD; Robert Greenlee, PhD, MPH; Barbara Haley, MD; Jennifer Klemp, PhD, MPH; Ingrid Lizarraga, MBBS; Joan Neuner, MD, MPH; Adedayo A. Onitilo, MD, PhD, MSCR, FACP; Amelie G. Ramirez, Ph.D., MPH; Priyanka Sharma, MD; Amy Trentham-Dietz, PhD; and Lee Gravatt Wilke, MD, FACS; the Greater Plains Collaborative informatics team who integrated tumor registry data and selected the study samples: Bhargav Adagarla, Daniel Connolly, Tamara McMahaon, Glenn Bushee, Supreet Kathpalia, Jim McClay, Enelda Mendonca, Tom MishSusan Morrison, Phillip Reeder, Nicholas Smith, Laurel Verhagen, and Kathy Williams.

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Breast cancer
  • Disparities
  • Neoadjuvant chemotherapy
  • Socioeconomic status

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