The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort

POST study consortium

doi:10.1097/mpa.0000000000001850

The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort

POST study consortium

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

Original language	English (US)
Pages (from-to)	852-858
Number of pages	7
Journal	Pancreas
Volume	50
Issue number	6
DOIs	https://doi.org/10.1097/mpa.0000000000001850
State	Published - 2021

Bibliographical note

Funding Information:
From the *Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH; †School of Public Health, University of Minnesota, Minneapolis, MN; ‡Department of Surgery, University of Chicago, Chicago, IL; §Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; ||Department of General Surgery, Cleveland Clinic, Cleveland, OH; ¶Division of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD; #Department of Pediatrics, **Department of Surgery, University of Minnesota Medical School, Minneapolis, MN; ††Department of Surgery, University of California San Francisco, San Francisco, CA; ‡‡Department of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX; §§Division of Surgery, Cincinnati Children's Hospital Medical Center; ||||Department of Surgery, ¶¶Department of Pediatrics, University of Cincinnati, Cincinnati, OH; ##Division of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC; ***Department of Medicine, University of Louisville, Louisville, KY; †††Department of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH; ‡‡‡Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§§Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN; ||||||Division of Pediatric Gastroenterology, Cincinnati Children's Hospital, Cincinnati, OH; and ¶¶¶Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. Received for publication November 25, 2020; accepted June 11, 2021. Address correspondence to: Luis F. Lara, MD, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Room 226, Columbus, OH 43210 (e‐mail: Luis.Lara@osumc.edu). Prospective Observational Study of TPIAT (POST) consortium was supported by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01-DK109124, PI M. Bellin). All authors participated in study concept and design, drafting and critical revision of the manuscript, and technical support as part of the POST consortium. L.F.L., S.W., J.S.H., and M.D.B. also participated in data acquisition, statistical analysis and interpretation of the data, drafting of the manuscript, final revision, and study supervision. L.F.F. is a consultant for Medtronic and Abbvie and a speaker for Nestle. S.C. did not declare conflict of interest related to the article. The remaining authors declare no conflict of interest. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001850

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

AP - acute pancreatitis
CP - chronic pancreatitis
IEQ - islet equivalents
IEQ/kg - islet equivalents per kilogram
POST - Prospective Observational Study of TPIAT consortium
TP - total pancreatectomy
TPIAT - total pancreatectomy with islet autotransplantation
alcohol
anxiety
depression
islet autotransplantation
mg/d - morphine equivalents milligrams per day
smoking
total pancreatectomy

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Observational Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/mpa.0000000000001850

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The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort. / POST study consortium.
In: Pancreas, Vol. 50, No. 6, 2021, p. 852-858.

Research output: Contribution to journal › Article › peer-review

POST study consortium 2021, 'The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort', Pancreas, vol. 50, no. 6, pp. 852-858. https://doi.org/10.1097/mpa.0000000000001850

@article{13495d38048745c3acb93887d989de85,

title = "The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort",

abstract = "Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.",

keywords = "AP - acute pancreatitis, CP - chronic pancreatitis, IEQ - islet equivalents, IEQ/kg - islet equivalents per kilogram, POST - Prospective Observational Study of TPIAT consortium, TP - total pancreatectomy, TPIAT - total pancreatectomy with islet autotransplantation, alcohol, anxiety, depression, islet autotransplantation, mg/d - morphine equivalents milligrams per day, smoking, total pancreatectomy",

author = "{POST study consortium} and Lara, {Luis F.} and Solvejg Wastvedt and Hodges, {James S.} and Piotr Witkowski and Martin Wijkstrom and Walsh, {R. Matthew} and Singh, {Vikesh K.} and Schwarzenberg, {Sarah J.} and Pruett, {Timothy L.} and Andrew Posselt and Bashoo Naziruddin and Nathan, {Jaimie D.} and Morgan, {Katherine A.} and Rebecca Mitchell and Kirchner, {Varvara A.} and Mokshagundam, {Sriprakash L.} and Betul Hatipoglu and Gardner, {Timothy B.} and Freeman, {Martin L.} and Srinath Chinnakotla and Beilman, {Gregory J.} and Maisam Abu-El-Haija and Conwell, {Darwin L.} and Bellin, {Melena D.}",

note = "Funding Information: From the *Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH; †School of Public Health, University of Minnesota, Minneapolis, MN; ‡Department of Surgery, University of Chicago, Chicago, IL; §Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; ||Department of General Surgery, Cleveland Clinic, Cleveland, OH; ¶Division of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD; #Department of Pediatrics, **Department of Surgery, University of Minnesota Medical School, Minneapolis, MN; ††Department of Surgery, University of California San Francisco, San Francisco, CA; ‡‡Department of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX; §§Division of Surgery, Cincinnati Children's Hospital Medical Center; ||||Department of Surgery, ¶¶Department of Pediatrics, University of Cincinnati, Cincinnati, OH; ##Division of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC; ***Department of Medicine, University of Louisville, Louisville, KY; †††Department of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH; ‡‡‡Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§§Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN; ||||||Division of Pediatric Gastroenterology, Cincinnati Children's Hospital, Cincinnati, OH; and ¶¶¶Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. Received for publication November 25, 2020; accepted June 11, 2021. Address correspondence to: Luis F. Lara, MD, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Room 226, Columbus, OH 43210 (e‐mail: Luis.Lara@osumc.edu). Prospective Observational Study of TPIAT (POST) consortium was supported by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01-DK109124, PI M. Bellin). All authors participated in study concept and design, drafting and critical revision of the manuscript, and technical support as part of the POST consortium. L.F.L., S.W., J.S.H., and M.D.B. also participated in data acquisition, statistical analysis and interpretation of the data, drafting of the manuscript, final revision, and study supervision. L.F.F. is a consultant for Medtronic and Abbvie and a speaker for Nestle. S.C. did not declare conflict of interest related to the article. The remaining authors declare no conflict of interest. Copyright {\textcopyright} 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001850 Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

year = "2021",

doi = "10.1097/mpa.0000000000001850",

language = "English (US)",

volume = "50",

pages = "852--858",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation

T2 - A Report from the Prospective Observational Study of TPIAT Cohort

AU - POST study consortium

AU - Lara, Luis F.

AU - Wastvedt, Solvejg

AU - Hodges, James S.

AU - Witkowski, Piotr

AU - Wijkstrom, Martin

AU - Walsh, R. Matthew

AU - Singh, Vikesh K.

AU - Schwarzenberg, Sarah J.

AU - Pruett, Timothy L.

AU - Posselt, Andrew

AU - Naziruddin, Bashoo

AU - Nathan, Jaimie D.

AU - Morgan, Katherine A.

AU - Mitchell, Rebecca

AU - Kirchner, Varvara A.

AU - Mokshagundam, Sriprakash L.

AU - Hatipoglu, Betul

AU - Gardner, Timothy B.

AU - Freeman, Martin L.

AU - Chinnakotla, Srinath

AU - Beilman, Gregory J.

AU - Abu-El-Haija, Maisam

AU - Conwell, Darwin L.

AU - Bellin, Melena D.

N1 - Funding Information: From the *Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH; †School of Public Health, University of Minnesota, Minneapolis, MN; ‡Department of Surgery, University of Chicago, Chicago, IL; §Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; ||Department of General Surgery, Cleveland Clinic, Cleveland, OH; ¶Division of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD; #Department of Pediatrics, **Department of Surgery, University of Minnesota Medical School, Minneapolis, MN; ††Department of Surgery, University of California San Francisco, San Francisco, CA; ‡‡Department of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX; §§Division of Surgery, Cincinnati Children's Hospital Medical Center; ||||Department of Surgery, ¶¶Department of Pediatrics, University of Cincinnati, Cincinnati, OH; ##Division of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC; ***Department of Medicine, University of Louisville, Louisville, KY; †††Department of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH; ‡‡‡Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§§Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN; ||||||Division of Pediatric Gastroenterology, Cincinnati Children's Hospital, Cincinnati, OH; and ¶¶¶Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. Received for publication November 25, 2020; accepted June 11, 2021. Address correspondence to: Luis F. Lara, MD, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Room 226, Columbus, OH 43210 (e‐mail: Luis.Lara@osumc.edu). Prospective Observational Study of TPIAT (POST) consortium was supported by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01-DK109124, PI M. Bellin). All authors participated in study concept and design, drafting and critical revision of the manuscript, and technical support as part of the POST consortium. L.F.L., S.W., J.S.H., and M.D.B. also participated in data acquisition, statistical analysis and interpretation of the data, drafting of the manuscript, final revision, and study supervision. L.F.F. is a consultant for Medtronic and Abbvie and a speaker for Nestle. S.C. did not declare conflict of interest related to the article. The remaining authors declare no conflict of interest. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001850 Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

AB - Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

KW - AP - acute pancreatitis

KW - CP - chronic pancreatitis

KW - IEQ - islet equivalents

KW - IEQ/kg - islet equivalents per kilogram

KW - POST - Prospective Observational Study of TPIAT consortium

KW - TP - total pancreatectomy

KW - TPIAT - total pancreatectomy with islet autotransplantation

KW - alcohol

KW - anxiety

KW - depression

KW - islet autotransplantation

KW - mg/d - morphine equivalents milligrams per day

KW - smoking

KW - total pancreatectomy

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U2 - 10.1097/mpa.0000000000001850

DO - 10.1097/mpa.0000000000001850

M3 - Article

C2 - 34347725

AN - SCOPUS:85113183719

SN - 0885-3177

VL - 50

SP - 852

EP - 858

JO - Pancreas

JF - Pancreas

IS - 6

ER -

The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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