The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort

POST study consortium

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

Original languageEnglish (US)
Pages (from-to)852-858
Number of pages7
JournalPancreas
Volume50
Issue number6
DOIs
StatePublished - Jul 1 2021

Bibliographical note

Funding Information:
From the *Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH; †School of Public Health, University of Minnesota, Minneapolis, MN; ‡Department of Surgery, University of Chicago, Chicago, IL; §Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; ||Department of General Surgery, Cleveland Clinic, Cleveland, OH; ¶Division of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD; #Department of Pediatrics, **Department of Surgery, University of Minnesota Medical School, Minneapolis, MN; ††Department of Surgery, University of California San Francisco, San Francisco, CA; ‡‡Department of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX; §§Division of Surgery, Cincinnati Children's Hospital Medical Center; ||||Department of Surgery, ¶¶Department of Pediatrics, University of Cincinnati, Cincinnati, OH; ##Division of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC; ***Department of Medicine, University of Louisville, Louisville, KY; †††Department of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH; ‡‡‡Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§§Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN; ||||||Division of Pediatric Gastroenterology, Cincinnati Children's Hospital, Cincinnati, OH; and ¶¶¶Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. Received for publication November 25, 2020; accepted June 11, 2021. Address correspondence to: Luis F. Lara, MD, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Room 226, Columbus, OH 43210 (e‐mail: Luis.Lara@osumc.edu). Prospective Observational Study of TPIAT (POST) consortium was supported by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK, R01-DK109124, PI M. Bellin). All authors participated in study concept and design, drafting and critical revision of the manuscript, and technical support as part of the POST consortium. L.F.L., S.W., J.S.H., and M.D.B. also participated in data acquisition, statistical analysis and interpretation of the data, drafting of the manuscript, final revision, and study supervision. L.F.F. is a consultant for Medtronic and Abbvie and a speaker for Nestle. S.C. did not declare conflict of interest related to the article. The remaining authors declare no conflict of interest. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001850

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • AP - acute pancreatitis
  • CP - chronic pancreatitis
  • IEQ - islet equivalents
  • IEQ/kg - islet equivalents per kilogram
  • POST - Prospective Observational Study of TPIAT consortium
  • TP - total pancreatectomy
  • TPIAT - total pancreatectomy with islet autotransplantation
  • alcohol
  • anxiety
  • depression
  • islet autotransplantation
  • mg/d - morphine equivalents milligrams per day
  • smoking
  • total pancreatectomy

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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