TY - JOUR
T1 - The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation
T2 - A Report from the Prospective Observational Study of TPIAT Cohort
AU - POST study consortium
AU - Lara, Luis F.
AU - Wastvedt, Solvejg
AU - Hodges, James S.
AU - Witkowski, Piotr
AU - Wijkstrom, Martin
AU - Walsh, R. Matthew
AU - Singh, Vikesh K.
AU - Schwarzenberg, Sarah J.
AU - Pruett, Timothy L.
AU - Posselt, Andrew
AU - Naziruddin, Bashoo
AU - Nathan, Jaimie D.
AU - Morgan, Katherine A.
AU - Mitchell, Rebecca
AU - Kirchner, Varvara A.
AU - Mokshagundam, Sriprakash L.
AU - Hatipoglu, Betul
AU - Gardner, Timothy B.
AU - Freeman, Martin L.
AU - Chinnakotla, Srinath
AU - Beilman, Gregory J.
AU - Abu-El-Haija, Maisam
AU - Conwell, Darwin L.
AU - Bellin, Melena D.
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.
AB - Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.
KW - AP - acute pancreatitis
KW - CP - chronic pancreatitis
KW - IEQ - islet equivalents
KW - IEQ/kg - islet equivalents per kilogram
KW - POST - Prospective Observational Study of TPIAT consortium
KW - TP - total pancreatectomy
KW - TPIAT - total pancreatectomy with islet autotransplantation
KW - alcohol
KW - anxiety
KW - depression
KW - islet autotransplantation
KW - mg/d - morphine equivalents milligrams per day
KW - smoking
KW - total pancreatectomy
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UR - http://www.scopus.com/inward/citedby.url?scp=85113183719&partnerID=8YFLogxK
U2 - 10.1097/mpa.0000000000001850
DO - 10.1097/mpa.0000000000001850
M3 - Article
C2 - 34347725
AN - SCOPUS:85113183719
SN - 0885-3177
VL - 50
SP - 852
EP - 858
JO - Pancreas
JF - Pancreas
IS - 6
ER -