The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients with Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report from the Prospective Observational Study of TPIAT Cohort

POST study consortium

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Methods We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. Results Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). Conclusions Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

Original languageEnglish (US)
Pages (from-to)852-858
Number of pages7
JournalPancreas
Volume50
Issue number6
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • AP - acute pancreatitis
  • CP - chronic pancreatitis
  • IEQ - islet equivalents
  • IEQ/kg - islet equivalents per kilogram
  • POST - Prospective Observational Study of TPIAT consortium
  • TP - total pancreatectomy
  • TPIAT - total pancreatectomy with islet autotransplantation
  • alcohol
  • anxiety
  • depression
  • islet autotransplantation
  • mg/d - morphine equivalents milligrams per day
  • smoking
  • total pancreatectomy

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Observational Study

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