The Association of Serum Carotenoids, Tocopherols, and Ascorbic Acid With Rapid Kidney Function Decline

The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Kristin M. Hirahatake, David R Jacobs Jr, Myron D Gross, Kirsten B. Bibbins-Domingo, Michael G. Shlipak, Holly Mattix-Kramer, Andrew O. Odegaard

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Nutritional intervention targeting dietary intake modification is a major component of treatment for chronic kidney disease; however, little is known about the relationship between dietary intake and kidney function decline in individuals with preserved kidney function. Design and methods: In this prospective cohort study we examined the association of biomarkers of dietary intake with kidney function decline over a 5-year interval in 2,152 men and women with cystatin-C–based estimated glomerular filtration rate > 60 mL/minute/1.73 m2 from the Coronary Artery Risk Development in Young Adults study. The biomarkers of interest included carotenoids, tocopherols, and ascorbic acid. Multivariable logistic regression was used to explore the relationship between serum concentrations of the sum of 4 carotenoids (α-carotene, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin), lycopene, α-tocopherol, γ-tocopherol, and ascorbic acid and rapid kidney function decline, defined as.15% decline in cystatin-C–based estimated glomerular filtration rate over 5 years. Results: During the 5-year follow-up, 290 participants (13.5%) experienced rapid kidney function decline. Relative to individuals in the lowest quartile of serum carotenoids, those in the highest quartile had significantly lower odds of rapid kidney function decline in the fully adjusted model (odds ratio, 0.51; 95% confidence interval [CI], 0.32-0.80; P trend,.02). No association of levels of serum tocopherols, ascorbic acid, or lycopene with kidney function decline was found. There was no evidence that results differed for individuals with hypertension or diabetes. Conclusions: These results demonstrate that higher serum carotenoid levels, reflective of a fruit- and vegetable-rich dietary pattern, inversely associate with rapid kidney function decline in early middle adulthood and provide insight into how diet might play a role in chronic kidney disease prevention.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalJournal of Renal Nutrition
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Tocopherols
Carotenoids
Ascorbic Acid
Young Adult
Coronary Vessels
Kidney
Serum
Cystatins
Glomerular Filtration Rate
Chronic Renal Insufficiency
Biomarkers
Diet Therapy
Lutein
Vegetables
Fruit
Cohort Studies
Logistic Models
Odds Ratio
Prospective Studies
Confidence Intervals

PubMed: MeSH publication types

  • Journal Article

Cite this

The Association of Serum Carotenoids, Tocopherols, and Ascorbic Acid With Rapid Kidney Function Decline : The Coronary Artery Risk Development in Young Adults (CARDIA) Study. / Hirahatake, Kristin M.; Jacobs Jr, David R; Gross, Myron D; Bibbins-Domingo, Kirsten B.; Shlipak, Michael G.; Mattix-Kramer, Holly; Odegaard, Andrew O.

In: Journal of Renal Nutrition, Vol. 29, No. 1, 01.01.2019, p. 65-73.

Research output: Contribution to journalArticle

Hirahatake, Kristin M. ; Jacobs Jr, David R ; Gross, Myron D ; Bibbins-Domingo, Kirsten B. ; Shlipak, Michael G. ; Mattix-Kramer, Holly ; Odegaard, Andrew O. / The Association of Serum Carotenoids, Tocopherols, and Ascorbic Acid With Rapid Kidney Function Decline : The Coronary Artery Risk Development in Young Adults (CARDIA) Study. In: Journal of Renal Nutrition. 2019 ; Vol. 29, No. 1. pp. 65-73.
@article{32c9199c88694d68aadac7ed301edc6e,
title = "The Association of Serum Carotenoids, Tocopherols, and Ascorbic Acid With Rapid Kidney Function Decline: The Coronary Artery Risk Development in Young Adults (CARDIA) Study",
abstract = "Objective: Nutritional intervention targeting dietary intake modification is a major component of treatment for chronic kidney disease; however, little is known about the relationship between dietary intake and kidney function decline in individuals with preserved kidney function. Design and methods: In this prospective cohort study we examined the association of biomarkers of dietary intake with kidney function decline over a 5-year interval in 2,152 men and women with cystatin-C–based estimated glomerular filtration rate > 60 mL/minute/1.73 m2 from the Coronary Artery Risk Development in Young Adults study. The biomarkers of interest included carotenoids, tocopherols, and ascorbic acid. Multivariable logistic regression was used to explore the relationship between serum concentrations of the sum of 4 carotenoids (α-carotene, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin), lycopene, α-tocopherol, γ-tocopherol, and ascorbic acid and rapid kidney function decline, defined as.15{\%} decline in cystatin-C–based estimated glomerular filtration rate over 5 years. Results: During the 5-year follow-up, 290 participants (13.5{\%}) experienced rapid kidney function decline. Relative to individuals in the lowest quartile of serum carotenoids, those in the highest quartile had significantly lower odds of rapid kidney function decline in the fully adjusted model (odds ratio, 0.51; 95{\%} confidence interval [CI], 0.32-0.80; P trend,.02). No association of levels of serum tocopherols, ascorbic acid, or lycopene with kidney function decline was found. There was no evidence that results differed for individuals with hypertension or diabetes. Conclusions: These results demonstrate that higher serum carotenoid levels, reflective of a fruit- and vegetable-rich dietary pattern, inversely associate with rapid kidney function decline in early middle adulthood and provide insight into how diet might play a role in chronic kidney disease prevention.",
author = "Hirahatake, {Kristin M.} and {Jacobs Jr}, {David R} and Gross, {Myron D} and Bibbins-Domingo, {Kirsten B.} and Shlipak, {Michael G.} and Holly Mattix-Kramer and Odegaard, {Andrew O.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1053/j.jrn.2018.05.008",
language = "English (US)",
volume = "29",
pages = "65--73",
journal = "Journal of Renal Nutrition",
issn = "1051-2276",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The Association of Serum Carotenoids, Tocopherols, and Ascorbic Acid With Rapid Kidney Function Decline

T2 - The Coronary Artery Risk Development in Young Adults (CARDIA) Study

AU - Hirahatake, Kristin M.

AU - Jacobs Jr, David R

AU - Gross, Myron D

AU - Bibbins-Domingo, Kirsten B.

AU - Shlipak, Michael G.

AU - Mattix-Kramer, Holly

AU - Odegaard, Andrew O.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Nutritional intervention targeting dietary intake modification is a major component of treatment for chronic kidney disease; however, little is known about the relationship between dietary intake and kidney function decline in individuals with preserved kidney function. Design and methods: In this prospective cohort study we examined the association of biomarkers of dietary intake with kidney function decline over a 5-year interval in 2,152 men and women with cystatin-C–based estimated glomerular filtration rate > 60 mL/minute/1.73 m2 from the Coronary Artery Risk Development in Young Adults study. The biomarkers of interest included carotenoids, tocopherols, and ascorbic acid. Multivariable logistic regression was used to explore the relationship between serum concentrations of the sum of 4 carotenoids (α-carotene, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin), lycopene, α-tocopherol, γ-tocopherol, and ascorbic acid and rapid kidney function decline, defined as.15% decline in cystatin-C–based estimated glomerular filtration rate over 5 years. Results: During the 5-year follow-up, 290 participants (13.5%) experienced rapid kidney function decline. Relative to individuals in the lowest quartile of serum carotenoids, those in the highest quartile had significantly lower odds of rapid kidney function decline in the fully adjusted model (odds ratio, 0.51; 95% confidence interval [CI], 0.32-0.80; P trend,.02). No association of levels of serum tocopherols, ascorbic acid, or lycopene with kidney function decline was found. There was no evidence that results differed for individuals with hypertension or diabetes. Conclusions: These results demonstrate that higher serum carotenoid levels, reflective of a fruit- and vegetable-rich dietary pattern, inversely associate with rapid kidney function decline in early middle adulthood and provide insight into how diet might play a role in chronic kidney disease prevention.

AB - Objective: Nutritional intervention targeting dietary intake modification is a major component of treatment for chronic kidney disease; however, little is known about the relationship between dietary intake and kidney function decline in individuals with preserved kidney function. Design and methods: In this prospective cohort study we examined the association of biomarkers of dietary intake with kidney function decline over a 5-year interval in 2,152 men and women with cystatin-C–based estimated glomerular filtration rate > 60 mL/minute/1.73 m2 from the Coronary Artery Risk Development in Young Adults study. The biomarkers of interest included carotenoids, tocopherols, and ascorbic acid. Multivariable logistic regression was used to explore the relationship between serum concentrations of the sum of 4 carotenoids (α-carotene, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin), lycopene, α-tocopherol, γ-tocopherol, and ascorbic acid and rapid kidney function decline, defined as.15% decline in cystatin-C–based estimated glomerular filtration rate over 5 years. Results: During the 5-year follow-up, 290 participants (13.5%) experienced rapid kidney function decline. Relative to individuals in the lowest quartile of serum carotenoids, those in the highest quartile had significantly lower odds of rapid kidney function decline in the fully adjusted model (odds ratio, 0.51; 95% confidence interval [CI], 0.32-0.80; P trend,.02). No association of levels of serum tocopherols, ascorbic acid, or lycopene with kidney function decline was found. There was no evidence that results differed for individuals with hypertension or diabetes. Conclusions: These results demonstrate that higher serum carotenoid levels, reflective of a fruit- and vegetable-rich dietary pattern, inversely associate with rapid kidney function decline in early middle adulthood and provide insight into how diet might play a role in chronic kidney disease prevention.

UR - http://www.scopus.com/inward/record.url?scp=85051081280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051081280&partnerID=8YFLogxK

U2 - 10.1053/j.jrn.2018.05.008

DO - 10.1053/j.jrn.2018.05.008

M3 - Article

VL - 29

SP - 65

EP - 73

JO - Journal of Renal Nutrition

JF - Journal of Renal Nutrition

SN - 1051-2276

IS - 1

ER -