The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study

Aubrey K. Hubbard; Michaela Richardson; Michelle A. Rosesler; Adina Cioc; Phuong L. Nguyen; Erica Warlick; Jenny N. Poynter

doi:10.1080/10428194.2020.1869962

The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study

Aubrey K. Hubbard, Michaela Richardson, Michelle A. Rosesler, Adina Cioc, Phuong L. Nguyen, Erica Warlick, Jenny N. Poynter

Research output: Contribution to journal › Article › peer-review

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.

Original language	English (US)
Pages (from-to)	1474-1481
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	62
Issue number	6
Early online date	Jan 8 2021
DOIs	https://doi.org/10.1080/10428194.2020.1869962
State	Published - Jun 2021

Bibliographical note

Funding Information:
The study was funded by a National Institutes of Health grant [R01 CA142714 to J.N.P] and supported by a grant from the National Institutes of Health [T32 CA099936 to A.K.H].

Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Myelodysplastic syndromes
epidemiology
non-steroidal anti-inflammatory drug
Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Humans
Risk Factors
Minnesota/epidemiology
Myelodysplastic Syndromes/chemically induced
Adult
Pharmaceutical Preparations
Case-Control Studies

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2020.1869962

https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1869962

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Hubbard, A. K., Richardson, M., Rosesler, M. A., Cioc, A., Nguyen, P. L., Warlick, E., & Poynter, J. N. (2021). The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study. Leukemia and Lymphoma, 62(6), 1474-1481. https://doi.org/10.1080/10428194.2020.1869962

The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study. / Hubbard, Aubrey K.; Richardson, Michaela; Rosesler, Michelle A. et al.
In: Leukemia and Lymphoma, Vol. 62, No. 6, 06.2021, p. 1474-1481.

Research output: Contribution to journal › Article › peer-review

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title = "The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study",

abstract = "Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.",

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author = "Hubbard, {Aubrey K.} and Michaela Richardson and Rosesler, {Michelle A.} and Adina Cioc and Nguyen, {Phuong L.} and Erica Warlick and Poynter, {Jenny N.}",

note = "Funding Information: The study was funded by a National Institutes of Health grant [R01 CA142714 to J.N.P] and supported by a grant from the National Institutes of Health [T32 CA099936 to A.K.H]. Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

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AU - Rosesler, Michelle A.

AU - Cioc, Adina

AU - Nguyen, Phuong L.

AU - Warlick, Erica

AU - Poynter, Jenny N.

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KW - Myelodysplastic Syndromes/chemically induced

KW - Adult

KW - Pharmaceutical Preparations

KW - Case-Control Studies

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ER -

The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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