Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.
Bibliographical noteFunding Information:
The study was funded by a National Institutes of Health grant [R01 CA142714 to J.N.P] and supported by a grant from the National Institutes of Health [T32 CA099936 to A.K.H].
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
- Myelodysplastic syndromes
- non-steroidal anti-inflammatory drug
- Anti-Inflammatory Agents, Non-Steroidal/adverse effects
- Risk Factors
- Myelodysplastic Syndromes/chemically induced
- Pharmaceutical Preparations
- Case-Control Studies
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural