TY - JOUR
T1 - The aric carotid mri study of blood cellular markers
T2 - An inverse association of monocyte myeloperoxidase content with peripheral arterial disease
AU - Matijevic, Nena
AU - Wu, Kenneth K.
AU - Nidkarni, Nivedita
AU - Heiss, Gerardo
AU - Folsom, Aaron R.
PY - 2011/4
Y1 - 2011/4
N2 - We evaluated the association of blood monocyte and platelet activation markers with the risk of peripheral artery disease (PAD) in a multicenter study of atherosclerosis among African American and Caucasian patients. Flow cytometric analysis of blood cells was performed in 1791 participants (209 cases with PAD and 1582 noncases) from the cross-sectional Atherosclerosis Risk in Communities Carotid Magnetic Resonance Imaging ([MRI] ARIC Carotid MRI) Study to assess platelet glycoproteins IIb and IIIa, P-selectin, CD40 ligand, platelet-leukocyte aggregates, monocyte lipopolysaccharide receptor, toll-like receptors (TLRs) 2 and 4, P-selectin glycoprotein ligand 1, cyclooxygenase 2, and myeloperoxidase. Multivariate regression analyses evaluated the association of cellular markers with the risk of PAD. After adjusting for age, race, and gender, platelet CD40L, and monocyte myeloperoxidase (mMPO) levels were significantly lower (P <.001), and monocyte TLR-4 levels were higher (P =.03) in patients with PAD. With additional adjustments for conventional risk factors, mMPO remained inversely and independently associated with the risk of PAD (odds ratio [OR]: 0.35, P =.01).
AB - We evaluated the association of blood monocyte and platelet activation markers with the risk of peripheral artery disease (PAD) in a multicenter study of atherosclerosis among African American and Caucasian patients. Flow cytometric analysis of blood cells was performed in 1791 participants (209 cases with PAD and 1582 noncases) from the cross-sectional Atherosclerosis Risk in Communities Carotid Magnetic Resonance Imaging ([MRI] ARIC Carotid MRI) Study to assess platelet glycoproteins IIb and IIIa, P-selectin, CD40 ligand, platelet-leukocyte aggregates, monocyte lipopolysaccharide receptor, toll-like receptors (TLRs) 2 and 4, P-selectin glycoprotein ligand 1, cyclooxygenase 2, and myeloperoxidase. Multivariate regression analyses evaluated the association of cellular markers with the risk of PAD. After adjusting for age, race, and gender, platelet CD40L, and monocyte myeloperoxidase (mMPO) levels were significantly lower (P <.001), and monocyte TLR-4 levels were higher (P =.03) in patients with PAD. With additional adjustments for conventional risk factors, mMPO remained inversely and independently associated with the risk of PAD (odds ratio [OR]: 0.35, P =.01).
KW - flow cytometry
KW - monocytes
KW - multicenter study
KW - myeloperoxidase
KW - peripheral arterial disease
KW - platelets
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U2 - 10.1177/0003319710385336
DO - 10.1177/0003319710385336
M3 - Article
C2 - 21406422
AN - SCOPUS:79952794227
VL - 62
SP - 237
EP - 244
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 3
ER -