The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8

Jacqueline D. Wright; Aaron R. Folsom; Josef Coresh; A. Richey Sharrett; David Couper; Lynne E. Wagenknecht; Thomas H. Mosley; Christie M. Ballantyne; Eric A. Boerwinkle; Wayne D. Rosamond; Gerardo Heiss

doi:10.1016/j.jacc.2021.04.035

The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8

Jacqueline D. Wright, Aaron R. Folsom, Josef Coresh, A. Richey Sharrett, David Couper, Lynne E. Wagenknecht, Thomas H. Mosley, Christie M. Ballantyne, Eric A. Boerwinkle, Wayne D. Rosamond, Gerardo Heiss

Epidemiology & Community Health

Research output: Contribution to journal › Article

60 Scopus citations

Abstract

ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.

Original language	English (US)
Pages (from-to)	2939-2959
Number of pages	21
Journal	Journal of the American College of Cardiology
Volume	77
Issue number	23
DOIs	https://doi.org/10.1016/j.jacc.2021.04.035
State	Published - Jun 15 2021

Bibliographical note

Funding Information:
In the last decade, ARIC has strengthened the engagement of outside investigators through ancillary studies following changes in the NHLBI’s approach to supporting cohort studies ( 114 , 115 ). A review of approved ancillary study proposals over time indicates increases in the number of proposals just before clinical examinations in 2011 to 2013 and 2018 to 19, suggesting a response by investigators to the “platform model” of support for clinic examination components through independently funded NIH grants. The most recent contract supported clinic examination, visit 7, included components supported by 12 independently funded ancillary studies. ARIC uses Medicare data on cohort participant hospitalizations and out-patient visits in combination with medical discharge records obtained by the study with consideration of the limitations of these administrative data ( 116 ). Engagement of new investigators in ARIC led to the development of new areas of research, enhanced existing research areas, and produced new research projects.

Publisher Copyright:
© 2020

Keywords

adult
cohort study
epidemiology
health disparity
risk factors
surveillance

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10.1016/j.jacc.2021.04.035

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title = "The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8",

abstract = "ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.",

keywords = "adult, cohort study, epidemiology, health disparity, risk factors, surveillance",

author = "Wright, {Jacqueline D.} and Folsom, {Aaron R.} and Josef Coresh and Sharrett, {A. Richey} and David Couper and Wagenknecht, {Lynne E.} and Mosley, {Thomas H.} and Ballantyne, {Christie M.} and Boerwinkle, {Eric A.} and Rosamond, {Wayne D.} and Gerardo Heiss",

note = "Funding Information: In the last decade, ARIC has strengthened the engagement of outside investigators through ancillary studies following changes in the NHLBI{\textquoteright}s approach to supporting cohort studies ( 114 , 115 ). A review of approved ancillary study proposals over time indicates increases in the number of proposals just before clinical examinations in 2011 to 2013 and 2018 to 19, suggesting a response by investigators to the “platform model” of support for clinic examination components through independently funded NIH grants. The most recent contract supported clinic examination, visit 7, included components supported by 12 independently funded ancillary studies. ARIC uses Medicare data on cohort participant hospitalizations and out-patient visits in combination with medical discharge records obtained by the study with consideration of the limitations of these administrative data ( 116 ). Engagement of new investigators in ARIC led to the development of new areas of research, enhanced existing research areas, and produced new research projects. Publisher Copyright: {\textcopyright} 2020",

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AU - Mosley, Thomas H.

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AU - Rosamond, Wayne D.

AU - Heiss, Gerardo

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AB - ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.

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The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8

Abstract

Bibliographical note

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