A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries. The variant also was related to longevity in the Icelandic population. However, because of the extreme rarity of A673T in non-Nordic populations, the association with Alzheimer's disease has not yet been formally replicated. Because the variant has not been reported among the Danes, we aimed to study its frequency among healthy middle-age twins and oldest-old singletons and explore the possible effects on longevity and cognitive abilities. Surprisingly, only 1 of 3487 unrelated Danes carried the A673T variant, (0.014% [95% CI 0.000-0.080]), which was significantly lower than in the other Nordic countries averaging to 0.43% (95% CI 0.40-0.46). In conclusion, the A673T variant is rarer in Danes than other Nordic countries, thus precluding assessment of association with longevity or cognitive functioning.
|Original language||English (US)|
|Journal||Neurobiology of Aging|
|State||Published - Oct 1 2015|
Bibliographical noteFunding Information:
The authors thank Lilja Jansson and Steen Gregersen for technical assistance. The study was supported by a grant from the US National Institutes of Health / National Institute on Aging , Grant No. P01 AG08761 ; by a grant from The Danish Agency for Science, Technology and Innovation , Grant No. 09–070081 , the INTERREG 4 A programme Syddanmark-Schleswig-K.E.R.N, the European Union's Seventh Framework Programme (FP7/2007–2011) under grant agreement n° 259679 and by grants from the Brødrene Hartmanns , Hørslev Fonden , A.P. Møller og Hustru Chastine MC-kinney Møllers foundations , and the Helsinki University Central Hospital . The Danish Aging Research Center is supported by a grant from the VELUX Foundation .
- Amyloid beta