The APOBEC3 family of retroelement restriction factors

Eric W. Refsland, Reuben S. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter

125 Scopus citations

Abstract

The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described with several proving capable of deaminating DNA and inhibiting HIV-1 replication. Ensuing studies on the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) restriction factors have uncovered a broad-spectrum innate defense network that suppresses the replication of numerous endogenous and exogenous DNA-based parasites. Although many viruses possess equally elaborate counter-defense mechanisms, the APOBEC3 enzymes offer a tantalizing possibility of leveraging innate immunity to fend off viral infection. Here, we focus on mechanisms of retroelement restriction by the APOBEC3 family of restriction enzymes, and we consider the therapeutic benefits, as well as the possible pathological consequences, of arming cells with active DNA deaminases.

Original languageEnglish (US)
Title of host publicationIntrinsic Immunity
PublisherSpringer Verlag
Pages1-27
Number of pages27
ISBN (Print)9783642377648
DOIs
StatePublished - 2013

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume371
ISSN (Print)0070-217X

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