The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells

Keyphrases

• Endothelial Cells 100%
• Statins 100%
• Heme oxygenase-1 (HO-1) 100%
• Antioxidant System 100%
• Defense Enzymes 100%
• Simvastatin 10%
• Antioxidant 10%
• Novel Pathways 10%
• Isoprenoids 10%
• Anti-inflammatory Activity 10%
• Protein Level 10%
• Cholesterol 10%
• Regulatory Elements 10%
• MRNA Level 10%
• Actinomycin D 10%
• Cycloheximide 10%
• Cell-derived 10%
• 5′-flanking Region 10%
• Protein Accumulation 10%
• Promoter Activity 10%
• Antiatherogenic 10%
• Pleiotropic Effects 10%
• Gene Promoter 10%
• Reporter Gene 10%
• Free Radical Formation 10%
• Cultured Endothelial Cells 10%
• Lovastatin 10%
• Heme oxygenase-1 Gene 10%
• Transcript Accumulation 10%
• Promoter Activation 10%
• L-NAME 10%
• Human Umbilical Vein 10%
• Transcriptional Expression 10%
• Gene Construct 10%
• Mevalonate 10%
• Protein Reduction 10%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 10%

Biochemistry, Genetics and Molecular Biology

• Defence Protein 100%
• Heme Oxygenase 100%
• Statin 100%
• Promoter Region 18%
• Messenger RNA 18%
• Regulatory Element 9%
• Gene Promoter 9%
• Upregulation 9%
• Mediator 9%
• DNA Flanking Region 9%
• Simvastatin 9%
• Cycloheximide 9%
• Gene Construct 9%
• Lovastatin 9%
• Reporter Gene 9%
• Dactinomycin 9%
• Arginine 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 100%
• Heme Oxygenase 1 100%
• Antioxidant 100%
• Anti-Inflammatory Drug 18%
• Messenger RNA 18%
• Dactinomycin 9%
• Protein 9%
• Free Radical 9%
• Isoprenoid 9%
• Mevinolin 9%
• Arginine Methyl Ester 9%
• Mevalonic Acid 9%
• Cycloheximide 9%
• Simvastatin 9%