The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae

Lina Abu Nada, Ahmed Al Subaie, Alaa Mansour, Xixi Wu, Mohamed Nur Abdallah, Haider Al-Waeli, Ala Ersheidat, Laura S. Stone, Monzur Murshed, Faleh Tamimi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aim: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Materials and Methods: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro-CT and histology. Results: Bone formation in bone defects was significantly lower (p < 0.05) in sertraline-treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower (p < 0.05) in sertraline-treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%). Conclusion: Sertraline hinders bone healing and implant osseointegration.

Original languageEnglish (US)
Pages (from-to)1485-1497
Number of pages13
JournalJournal of clinical periodontology
Volume45
Issue number12
DOIs
StatePublished - Dec 2018
Externally publishedYes

Keywords

  • bone healing
  • cytokine
  • osseointegration
  • proteome
  • selective serotonin reuptake inhibitors
  • sertraline

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    Abu Nada, L., Al Subaie, A., Mansour, A., Wu, X., Abdallah, M. N., Al-Waeli, H., Ersheidat, A., Stone, L. S., Murshed, M., & Tamimi, F. (2018). The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae. Journal of clinical periodontology, 45(12), 1485-1497. https://doi.org/10.1111/jcpe.13015