The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae

Lina Abu Nada, Ahmed Al Subaie, Alaa Mansour, Xixi Wu, Mohamed Nur Abdallah, Haider Al-Waeli, Ala Ersheidat, Laura S. Stone, Monzur Murshed, Faleh Tamimi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Aim: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Materials and Methods: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro-CT and histology. Results: Bone formation in bone defects was significantly lower (p < 0.05) in sertraline-treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower (p < 0.05) in sertraline-treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%). Conclusion: Sertraline hinders bone healing and implant osseointegration.

Original languageEnglish (US)
Pages (from-to)1485-1497
Number of pages13
JournalJournal of clinical periodontology
Volume45
Issue number12
DOIs
StatePublished - Dec 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by an operating grant from International Team for Implantology (ITI) fund no.1118_2015 to (F.Tamimi). The Fonds de recherche du Québec – Nature et technologies (FRQNT; MN.Abdallah), Canadian Foundation for Innovation (CFI, F. Tamimi), Natural Sciences and Engineering Research Council of Canada NSERC-Discovery (F. Tamimi), Canada Research Chair (F. Tamimi).

Funding Information:
Natural Sciences and Engineering Research Council of Canada NSERC-Discovery; International Team for Implantology ITI, Grant/Award Number: 1118_2015; Canadian Foundation for Innovation; Fonds de recherche du Québec – Nature et technologies FRQNT

Funding Information:
This work was supported by an operating grant from International Team for Implantology (ITI) fund no.1118_2015 to (F.Tamimi). The Fonds de recherche du Qu?bec ? Nature et technologies (FRQNT; MN.Abdallah), Canadian Foundation for Innovation (CFI, F. Tamimi), Natural Sciences and Engineering Research Council of Canada NSERC-Discovery (F. Tamimi), Canada Research Chair (F. Tamimi).

Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

  • bone healing
  • cytokine
  • osseointegration
  • proteome
  • selective serotonin reuptake inhibitors
  • sertraline

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