The anterior cingulate cortex and pain processing

Perry N. Fuchs, Yuan Bo Peng, Jessica A. Boyette-Davis, Megan L. Uhelski

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations


The neural network that contributes to the suffering which accompanies persistent pain states involves a number of brain regions. Of primary interest is the contribution of the cingulate cortex in processing the affective component of pain. The purpose of this review is to summarize recent data obtained using novel behavioral paradigms in animals based on measuring escape and/or avoidance of a noxious stimulus. These paradigms have successfully been used to study the nature of the neuroanatomical and neurochemical contributions of the anterior cingulate cortex (ACC) to higher order pain processing in rodents.

Original languageEnglish (US)
Article number35
JournalFrontiers in Integrative Neuroscience
Issue numberMAY
StatePublished - May 5 2014
Externally publishedYes


  • Anterior cingulate cortex
  • Pain
  • Pain affect
  • Place avoidance
  • Place escape


Dive into the research topics of 'The anterior cingulate cortex and pain processing'. Together they form a unique fingerprint.

Cite this