The amino acid composition of proteins: A method of analysis

R. Dennis Cook, R. F. Nassar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Four quasiloglinear models are proposed for describing relationships between the amino acid composition of proteins and the structure of the genetic code. The models allow estimation of base frequencies in all three codon positions and can be used to investigate "interactions" between any two codon positions. The estimation procedure proposed by Ohta and Kimura (Genetics 64 (1970), 387-395) is discussed and using two of the proposed quasiloglinear models an analysis of the amino acid composition of human cytochrome c is presented. The analysis suggests that of the six codons which code for leucine (CUU, CUC, CUA and CUG) do not occur in human cytochrome c.

Original languageEnglish (US)
Pages (from-to)64-83
Number of pages20
JournalTheoretical Population Biology
Issue number1
StatePublished - Feb 1975


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