The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination

Gordon R. Bernard, Antonio Artigas, Kenneth L. Brigham, Jean Carlet, Konrad Falke, Leonard Hudson, Maurice Lamy, Jean Roger Legall, Roger Spragg, Alan Morris, Belghith Cochin, Paul N. Lanken, Kenneth V. Leeper, John Marini, John F. Murray, Luis Oppenheimer, Antonio Pesenti, Lynne Reid, Jean Rinaldo, Jesus VillarB. Swefer Van Asbeck, Jean Francois Dhainaut, Jordi Mancebo, Michael Matthay, Barbara Meyrick, Didier Payen, Claude Perret, Alpha A. Fowler, Marie Denise Schaller, Thomas Hyers, William Knaus, Richard Matthay, Michael Pinsky, Roger C. Bone, Waldemar G. Johanson, Klaus Lewandowski, John Repine, Roberta Rodriguez-Roisin, Charis Roussos, Massimo A. Antonelli, Sadek Beloucif, David Bihari, Hilmar Burchardi, Francois LeMaire, Philipe Montravers, Thomas L. Petty, James Robotham, Warren Zapol

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Abstract

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American-European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.

Original languageEnglish (US)
Pages (from-to)818-824
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume149
Issue number3 I
DOIs
StatePublished - 1994

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    Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Spragg, R., Morris, A., Cochin, B., Lanken, P. N., Leeper, K. V., Marini, J., Murray, J. F., Oppenheimer, L., Pesenti, A., Reid, L., Rinaldo, J., ... Zapol, W. (1994). The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination. American journal of respiratory and critical care medicine, 149(3 I), 818-824. https://doi.org/10.1164/ajrccm.149.3.7509706