The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients

Xiaojing Xu, Lifang Han, Huaping Yang, Li Duan, Boting Zhou, Yingchun Zhao, Jian Qu, Rui Ma, Honghao Zhou, Zhaoqian Liu

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

eIF3a is the largest subunit of eukaryotic translation initiation factor 3, which has been suggested to affect tumor progression and activity of nucleotide excision repair pathway contributing to platinum resistance. The purpose of this study was to investigate possible mutations in promoter and exon regions of eIF3a gene and to assess whether eIF3a mutation status have prognostic and predictive significance in platinum-based chemotherapeutic lung cancer patients. 771 lung cancer patients were enrolled and followed up. These patients were newly diagnosed with incident lung cancer, which was confirmed histologically or cytologically, and accepted platinum-based chemotherapy for at least two cycles. Three novel mutations of eIF3a were found, including 11279G > A in intron 6, Arg438Lys in exon 9, 29671G > A in intron 15, with minor allele frequency of 0.16, 0.18, 0.16, respectively. A-carrier patients of rs3740556 conferred a significantly better platinum-based chemotherapy response (p<0.05) and seemed to live longer. eIF3a genetic polymorphisms can be considered as predictive tools for pretreatment evaluation of platinum-based chemotherapy. Lung cancer patients carrying rs3740556 A allele tended to have a favorable prognosis after treatment with platinum-based chemotherapy.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalLung Cancer
Volume79
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by National Science and Technology Main Project of China ( 2009ZX09304-003 ), National High-tech R&D Program of China (863 Program) ( 2009AA022704 ), National Natural Science Foundation of China ( 30572230 , 30873089 ) and Natural Science Foundation of Hunan Province of China ( 08JJ3058 ).

Keywords

  • EIF3a
  • Lung cancer
  • Platinum chemotherapy
  • Resistance
  • Survival analysis

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