The adjuvant action of polynucleotides

A. G. Johnson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Studies on the mechanism of adjuvant action of the homoribopolymers, polyadenylic acid complexed to polyuridylic acid, are reviewed. The available evidence suggests that polynucleotides stimulate several different immunocompetent cells, but that the adjuvant effect is most profound in instances of T cell deficiencies. Both the helper effect on antibody synthesis and effector activity in mediated immunity are elevated by this nontoxic adjuvant.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalRES Journal of the Reticuloendothelial Society
Volume14
Issue number5
StatePublished - Dec 1 1973

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Poly U
Polynucleotides
Poly A
Immunity
T-Lymphocytes
Antibodies

Cite this

The adjuvant action of polynucleotides. / Johnson, A. G.

In: RES Journal of the Reticuloendothelial Society, Vol. 14, No. 5, 01.12.1973, p. 441-448.

Research output: Contribution to journalArticle

Johnson, A. G. / The adjuvant action of polynucleotides. In: RES Journal of the Reticuloendothelial Society. 1973 ; Vol. 14, No. 5. pp. 441-448.
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