The adjuvant action of polynucleotides

Arthur G Johnson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Studies on the mechanism of adjuvant action of the homoribopolymers, polyadenylic acid complexed to polyuridylic acid, are reviewed. The available evidence suggests that polynucleotides stimulate several different immunocompetent cells, but that the adjuvant effect is most profound in instances of T cell deficiencies. Both the helper effect on antibody synthesis and effector activity in mediated immunity are elevated by this nontoxic adjuvant.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalRES Journal of the Reticuloendothelial Society
Issue number5
StatePublished - Dec 1 1973


Dive into the research topics of 'The adjuvant action of polynucleotides'. Together they form a unique fingerprint.

Cite this