TY - JOUR
T1 - The acquisition of purines by Trypanosomatids
AU - Cohn, Claudia C.
AU - Gottlieb, Michael
PY - 1997/6
Y1 - 1997/6
N2 - Parasites of the family Trypanosomatidae have an absolute requirement for purines, yet lack the intracellular machinery to synthesize their own purine ring de novo. As a result, the enzymes devoted to the transport and metabolism of purines are extremely important to the parasite. Here, Claudia Cohn and Michael Gottlieb emphasize the value of understanding purine salvage for the development of trypanocidal drugs, and discuss the putative transporters devoted to purine uptake.
AB - Parasites of the family Trypanosomatidae have an absolute requirement for purines, yet lack the intracellular machinery to synthesize their own purine ring de novo. As a result, the enzymes devoted to the transport and metabolism of purines are extremely important to the parasite. Here, Claudia Cohn and Michael Gottlieb emphasize the value of understanding purine salvage for the development of trypanocidal drugs, and discuss the putative transporters devoted to purine uptake.
UR - http://www.scopus.com/inward/record.url?scp=0030906370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030906370&partnerID=8YFLogxK
U2 - 10.1016/S0169-4758(97)01059-4
DO - 10.1016/S0169-4758(97)01059-4
M3 - Article
C2 - 15275076
AN - SCOPUS:0030906370
SN - 1471-4922
VL - 13
SP - 231
EP - 235
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 6
ER -