The accordion-HMQC: Heteronuclear correlations for a range of coupling constants

Klaus Zangger, Ian M. Armitage

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A method is presented for the simultaneous correlation of proton-heteronuclear fragments with varying coupling constants. This is achieved by incrementing the preparation delay, during the acquisition of a two-dimensional HMQC spectrum in accordion style. In addition to providing all correlations in a single spectrum, this approach also allows the extraction of proton-heteronuclear coupling constants from the indirect dimension. In addition, a theoretical analysis of the presented experiment is given which also allows for a better understanding of other accordion experiments, in particular the recently proposed ACCORD-HMBC. Results are shown for 15N-labeled urea, Cd-EDTA and the cadmium binding protein metallothionein.

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalMagnetic Resonance in Chemistry
Volume38
Issue number6
DOIs
StatePublished - Jun 2000

Keywords

  • 2D NMR
  • Accordion spectroscopy
  • Cd NMR
  • HMQC
  • Metallothionein
  • NMR

Fingerprint Dive into the research topics of 'The accordion-HMQC: Heteronuclear correlations for a range of coupling constants'. Together they form a unique fingerprint.

  • Cite this