The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

Kerrie B. Bouker; Todd C. Skaar; David S. Harburger; Rebecca B. Riggins; David R. Fernandez; Alan Zwart; Robert Clarke

doi:10.1016/j.cancergencyto.2006.12.008

The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

Kerrie B. Bouker, Todd C. Skaar, David S. Harburger, Rebecca B. Riggins, David R. Fernandez, Alan Zwart, Robert Clarke

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Loss or mutation of known tumor suppressor genes accounts for a small proportion of all breast cancers. We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer. We now report that the A4396G single nucleotide polymorphism in the IRF1 gene is more frequent in human breast cancer cell lines than in the general population (P = 0.01). Furthermore, A4396G is more frequently expressed in African American (black) than in European ancestry (white) subjects (n = 70 subjects; P ≤ 0.001), leading to a significant difference in genotype distribution between these populations (P = 0.002).

Original language	English (US)
Pages (from-to)	61-64
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	175
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2006.12.008
State	Published - May 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.cancergencyto.2006.12.008

Find It

Find It at U of M Libraries

Cite this

@article{a4ba770ac3ef4c9f9616905d9d91a0f4,

title = "The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines",

abstract = "Loss or mutation of known tumor suppressor genes accounts for a small proportion of all breast cancers. We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer. We now report that the A4396G single nucleotide polymorphism in the IRF1 gene is more frequent in human breast cancer cell lines than in the general population (P = 0.01). Furthermore, A4396G is more frequently expressed in African American (black) than in European ancestry (white) subjects (n = 70 subjects; P ≤ 0.001), leading to a significant difference in genotype distribution between these populations (P = 0.002).",

author = "Bouker, {Kerrie B.} and Skaar, {Todd C.} and Harburger, {David S.} and Riggins, {Rebecca B.} and Fernandez, {David R.} and Alan Zwart and Robert Clarke",

year = "2007",

month = may,

doi = "10.1016/j.cancergencyto.2006.12.008",

language = "English (US)",

volume = "175",

pages = "61--64",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

AU - Bouker, Kerrie B.

AU - Skaar, Todd C.

AU - Harburger, David S.

AU - Riggins, Rebecca B.

AU - Fernandez, David R.

AU - Zwart, Alan

AU - Clarke, Robert

PY - 2007/5

Y1 - 2007/5

N2 - Loss or mutation of known tumor suppressor genes accounts for a small proportion of all breast cancers. We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer. We now report that the A4396G single nucleotide polymorphism in the IRF1 gene is more frequent in human breast cancer cell lines than in the general population (P = 0.01). Furthermore, A4396G is more frequently expressed in African American (black) than in European ancestry (white) subjects (n = 70 subjects; P ≤ 0.001), leading to a significant difference in genotype distribution between these populations (P = 0.002).

AB - Loss or mutation of known tumor suppressor genes accounts for a small proportion of all breast cancers. We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer. We now report that the A4396G single nucleotide polymorphism in the IRF1 gene is more frequent in human breast cancer cell lines than in the general population (P = 0.01). Furthermore, A4396G is more frequently expressed in African American (black) than in European ancestry (white) subjects (n = 70 subjects; P ≤ 0.001), leading to a significant difference in genotype distribution between these populations (P = 0.002).

UR - http://www.scopus.com/inward/record.url?scp=34247842824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247842824&partnerID=8YFLogxK

U2 - 10.1016/j.cancergencyto.2006.12.008

DO - 10.1016/j.cancergencyto.2006.12.008

M3 - Article

C2 - 17498560

AN - SCOPUS:34247842824

SN - 0165-4608

VL - 175

SP - 61

EP - 64

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this