The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats

Michael Mindrinos, Fumiaki Katagiri, Guo Liang Yu, Frederick M. Ausubel

Research output: Contribution to journalArticlepeer-review

549 Scopus citations

Abstract

In plants, resistance to a pathogen is frequently correlated with a genetically defined interaction between a plant resistance gene and a corresponding pathogen avirulence gene. A simple model explains these gene-for-gene interactions: avirulence gene products generate signals (ligands), and resistance genes encode cognate receptors. The A. thaliana RPS2 gene confers resistance to the bacterial pathogen P. syringae carrying the avirulence gene avrRpt2. A map-based positional cloning strategy was used to identify RPS2. The identification of RPS2 was verified using a newly developed transient assay for RPS2 function and by genetic complementation in transgenic plants. RPS2 encodes a novel 105 kDa protein containing a leucine zipper, a nucleotide-binding site, and 14 imperfect leucine-rich repeats.

Original languageEnglish (US)
Pages (from-to)1089-1099
Number of pages11
JournalCell
Volume78
Issue number6
DOIs
StatePublished - Sep 23 1994

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