The 4D nucleome project.

J Dekker; Belmont AS; M Guttman; Leshyk VO; Lis JT; S Lomvardas; Mirny LA; O'Shea CC; Park PJ; B Ren; Politz JCR; J Shendure; S Zhong; 4D Nucleome Network

doi:10.1038/nature23884

The 4D nucleome project.

J Dekker
, Belmont AS
, M Guttman
, Leshyk VO
, Lis JT
, S Lomvardas
, Mirny LA
, O'Shea CC
, Park PJ
, B Ren
, Politz JCR
, J Shendure
, S Zhong
, 4D Nucleome Network

Administration (SoN)

Research output: Contribution to journal › Article › peer-review

570 Scopus citations

Abstract

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

Original language	Undefined/Unknown
Journal	Nature
DOIs	https://doi.org/10.1038/nature23884
State	Published - Sep 1 2017

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author = "J Dekker and Belmont AS and M Guttman and Leshyk VO and Lis JT and S Lomvardas and Mirny LA and O'Shea CC and Park PJ and B Ren and Politz JCR and J Shendure and S Zhong and Network, \{4D Nucleome\}",

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AU - Dekker, J

AU - AS, Belmont

AU - Guttman, M

AU - VO, Leshyk

AU - JT, Lis

AU - Lomvardas, S

AU - LA, Mirny

AU - CC, O'Shea

AU - PJ, Park

AU - Ren, B

AU - JCR, Politz

AU - Shendure, J

AU - Zhong, S

AU - Network, 4D Nucleome

PY - 2017/9/1

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N2 - The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

AB - The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

UR - https://europepmc.org/articles/PMC5617335

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DO - 10.1038/nature23884

M3 - Article

C2 - 28905911

SN - 0028-0836

JO - Nature

JF - Nature

ER -

The 4D nucleome project.

Abstract

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