The 14-alkyl- and 14-alkenyl-5β-methylindolomorphinan series provide δ-selective partial opioid agonists

Peter Grundt, Fernando Martinez-Bermejo, John W. Lewis, Stephen M. Husbands

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A series of 14β-alkyl- and 14β-alkenyl-5β-methylindolomorphinans was synthesized and evaluated in opioid binding and functional assays. While being relatively nonselective in binding assays, the 14-cinnamyl and 14-isopentyl members showed selective opioid δ-receptor partial agonist activity in [35S]GTPγS assays.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalHelvetica Chimica Acta
Volume86
Issue number3
DOIs
StatePublished - Apr 23 2003

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