Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
Bibliographical noteFunding Information:
1 This investigation was supported by U.S. Public Health Service Grants from the National Institute on Drug Abuse. * To whom all correspondence should be addressed: Depart-ment of Pharmacology, 3-260 Millard Hall, University of Minnesota, 435 Delaware St. S.E., Minneapolis, MN 55455 U.S.A.
Copyright 2014 Elsevier B.V., All rights reserved.
- Guinea-pig ileum
- Mouse vas deferens
- Opioid receptors