The μ, κ and δ properties of various opioid agonists

A. E. Takemori, Masako Ikeda, Philip S Portoghese

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalEuropean Journal of Pharmacology
Volume123
Issue number3
DOIs
StatePublished - Apr 29 1986

Fingerprint

Buprenorphine
Vas Deferens
Opioid Receptors
Opioid Analgesics
Guinea Pigs
Ligands
Muscles

Keywords

  • Guinea-pig ileum
  • Mouse vas deferens
  • Opioid receptors
  • β-CNA
  • β-FNA

Cite this

The μ, κ and δ properties of various opioid agonists. / Takemori, A. E.; Ikeda, Masako; Portoghese, Philip S.

In: European Journal of Pharmacology, Vol. 123, No. 3, 29.04.1986, p. 357-361.

Research output: Contribution to journalArticle

Takemori, A. E. ; Ikeda, Masako ; Portoghese, Philip S. / The μ, κ and δ properties of various opioid agonists. In: European Journal of Pharmacology. 1986 ; Vol. 123, No. 3. pp. 357-361.
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