Abstract
Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-361 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 123 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 29 1986 |
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Keywords
- Guinea-pig ileum
- Mouse vas deferens
- Opioid receptors
- β-CNA
- β-FNA
Cite this
The μ, κ and δ properties of various opioid agonists. / Takemori, A. E.; Ikeda, Masako; Portoghese, Philip S.
In: European Journal of Pharmacology, Vol. 123, No. 3, 29.04.1986, p. 357-361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The μ, κ and δ properties of various opioid agonists
AU - Takemori, A. E.
AU - Ikeda, Masako
AU - Portoghese, Philip S
PY - 1986/4/29
Y1 - 1986/4/29
N2 - Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
AB - Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
KW - Guinea-pig ileum
KW - Mouse vas deferens
KW - Opioid receptors
KW - β-CNA
KW - β-FNA
UR - http://www.scopus.com/inward/record.url?scp=0022600746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022600746&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90709-0
DO - 10.1016/0014-2999(86)90709-0
M3 - Article
VL - 123
SP - 357
EP - 361
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -