Abstract
Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-361 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 123 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 29 1986 |
Bibliographical note
Funding Information:1 This investigation was supported by U.S. Public Health Service Grants from the National Institute on Drug Abuse. * To whom all correspondence should be addressed: Depart-ment of Pharmacology, 3-260 Millard Hall, University of Minnesota, 435 Delaware St. S.E., Minneapolis, MN 55455 U.S.A.
Keywords
- Guinea-pig ileum
- Mouse vas deferens
- Opioid receptors
- β-CNA
- β-FNA