The μ, κ and δ properties of various opioid agonists

A. E. Takemori, Masako Ikeda, P. S. Portoghese

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Using the δ-enriched mouse vas deferens and the κ-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'μ, κ, δ and σ' opioid agonists were tested for their μ, κ and δ properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for μ and κ opioid receptors, respectively. Most ligands identified as specific agonists are in fact only selective and appear to interact at more than one receptor type.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalEuropean Journal of Pharmacology
Volume123
Issue number3
DOIs
StatePublished - Apr 29 1986

Bibliographical note

Funding Information:
1 This investigation was supported by U.S. Public Health Service Grants from the National Institute on Drug Abuse. * To whom all correspondence should be addressed: Depart-ment of Pharmacology, 3-260 Millard Hall, University of Minnesota, 435 Delaware St. S.E., Minneapolis, MN 55455 U.S.A.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Guinea-pig ileum
  • Mouse vas deferens
  • Opioid receptors
  • β-CNA
  • β-FNA

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