The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner; Barbara J. Stickney; Heidi E. Quist; Burt M. Sharp; Philip S Portoghese

doi:10.1016/S0014-2999(98)00477-4

The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner, Barbara J. Stickney, Heidi E. Quist, Burt M. Sharp, Philip S Portoghese

Medicinal Chemistry

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ₁-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ₁-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

Original language	English (US)
Journal	European Journal of Pharmacology
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00477-4
State	Published - Jul 31 1998

Fingerprint

naltrindole

Narcotic Antagonists

Allografts

Kidney

Opioid Receptors

Graft Survival

Kidney Transplantation

Therapeutics

Keywords

7-Benzylspiroindanylnaltrexone
Transplantation
δ-Opioid receptor

Cite this

Linner, K. M., Stickney, B. J., Quist, H. E., Sharp, B. M., & Portoghese, P. S. (1998). The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model. European Journal of Pharmacology, 354(1). https://doi.org/10.1016/S0014-2999(98)00477-4

The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model. / Linner, Kristin M.; Stickney, Barbara J.; Quist, Heidi E.; Sharp, Burt M.; Portoghese, Philip S.

In: European Journal of Pharmacology, Vol. 354, No. 1, 31.07.1998.

Research output: Contribution to journal › Article

Linner, KM, Stickney, BJ, Quist, HE, Sharp, BM & Portoghese, PS 1998, 'The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model', European Journal of Pharmacology, vol. 354, no. 1. https://doi.org/10.1016/S0014-2999(98)00477-4

Linner KM, Stickney BJ, Quist HE, Sharp BM, Portoghese PS. The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model. European Journal of Pharmacology. 1998 Jul 31;354(1). https://doi.org/10.1016/S0014-2999(98)00477-4

Linner, Kristin M. ; Stickney, Barbara J. ; Quist, Heidi E. ; Sharp, Burt M. ; Portoghese, Philip S. / The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model. In: European Journal of Pharmacology. 1998 ; Vol. 354, No. 1.

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10.1016/S0014-2999(98)00477-4