TY - JOUR
T1 - The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model
AU - Linner, Kristin M.
AU - Stickney, Barbara J.
AU - Quist, Heidi E.
AU - Sharp, Burt M.
AU - Portoghese, Philip S.
PY - 1998/7/31
Y1 - 1998/7/31
N2 - In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.
AB - In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.
KW - 7-Benzylspiroindanylnaltrexone
KW - Transplantation
KW - δ-Opioid receptor
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U2 - 10.1016/S0014-2999(98)00477-4
DO - 10.1016/S0014-2999(98)00477-4
M3 - Article
C2 - 9726640
AN - SCOPUS:0031658880
VL - 354
SP - R3-R5
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -