The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner; Barbara J. Stickney; Heidi E. Quist; Burt M. Sharp; Philip S. Portoghese

doi:10.1016/S0014-2999(98)00477-4

The δ₁-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner, Barbara J. Stickney, Heidi E. Quist, Burt M. Sharp, Philip S. Portoghese

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ₁-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ₁-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	R3-R5
Journal	European Journal of Pharmacology
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00477-4
State	Published - Jul 31 1998

Keywords

7-Benzylspiroindanylnaltrexone
Transplantation
δ-Opioid receptor

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10.1016/S0014-2999(98)00477-4

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title = "The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model",

abstract = "In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.",

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AU - Linner, Kristin M.

AU - Stickney, Barbara J.

AU - Quist, Heidi E.

AU - Sharp, Burt M.

AU - Portoghese, Philip S.

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AB - In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

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