The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner, Barbara J. Stickney, Heidi E. Quist, Burt M. Sharp, Philip S Portoghese

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume354
Issue number1
DOIs
StatePublished - Jul 31 1998

Fingerprint

naltrindole
Narcotic Antagonists
Allografts
Kidney
Opioid Receptors
Graft Survival
Kidney Transplantation
Therapeutics

Keywords

  • 7-Benzylspiroindanylnaltrexone
  • Transplantation
  • δ-Opioid receptor

Cite this

The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model. / Linner, Kristin M.; Stickney, Barbara J.; Quist, Heidi E.; Sharp, Burt M.; Portoghese, Philip S.

In: European Journal of Pharmacology, Vol. 354, No. 1, 31.07.1998.

Research output: Contribution to journalArticle

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