Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent

Krisztián Szigeti, Nikolett Hegedus, Kitti Rácz, Ildikó Horváth, Dániel S. Veres, Dávid Szöllosi, Ildikó Futó, Károly Módos, Tamás Bozó, Kinga Karlinger, Noémi Kovács, Zoltán Varga, Magor Babos, Ferenc Budán, Parasuraman Padmanabhan, Balázs Gulyás, Domokos Máthé

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Abstract

Background. The aim of this study was to develop and characterize a nanoparticle-based image-contrast platform which is biocompatible, chemically stable, and accessible for radiolabeling with 201 Tl. We explored whether this nanoparticle enhanced the T1 signal which might make it an MRI contrast agent as well. Methods. The physical properties of citrate-coated Prussian blue nanoparticles (PBNPs) (iron(II);iron(III);octadecacyanide) doped with 201 Tl isotope were characterized with atomic force microscopy, dynamic light scattering, and zeta potential measurement. PBNP biodistribution was determined by using SPECT and MRI following intravenous administration into C57BL6 mice. Activity concentrations (MBq/cm 3 ) were calculated from the SPECT scans for each dedicated volume of interest (VOI) of liver, kidneys, salivary glands, heart, lungs, and brain. Results. PBNP accumulation peaked at 2 hours after injection predominantly in the kidneys and the liver followed by a gradual decrease in activity in later time points. Conclusion. We synthetized, characterized, and radiolabeled a Prussian blue-based nanoparticle platform for contrast material applications. Its in vivo radiochemical stability and biodistribution open up the way for further diagnostic applications.

Original languageEnglish (US)
Article number2023604
JournalContrast Media and Molecular Imaging
Volume2018
DOIs
StatePublished - Apr 26 2018
Externally publishedYes

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    Szigeti, K., Hegedus, N., Rácz, K., Horváth, I., Veres, D. S., Szöllosi, D., Futó, I., Módos, K., Bozó, T., Karlinger, K., Kovács, N., Varga, Z., Babos, M., Budán, F., Padmanabhan, P., Gulyás, B., & Máthé, D. (2018). Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent. Contrast Media and Molecular Imaging, 2018, [2023604]. https://doi.org/10.1155/2018/2023604