Thalamic control of neocortical area formation in mice

Tou Yia Vue, Melody Lee, Yew Ei Tan, Zachary Werkhoven, Lynn Wang, Yasushi Nakagawa

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The mammalian neocortex undergoes dramatic transformation during development, from a seemingly homogenous sheet of neuroepithelial cells into a complex structure that is tangentially divided into discrete areas. This process is thought to be controlled by a combination of intrinsic patterning mechanisms within the cortex and afferent axonal projections from the thalamus. However, roles of thalamic afferents in the formation of areas are still poorly understood. In this study,weshow that genetically increasing or decreasing the size of the lateral geniculate nucleus of the mouse thalamus resulted in a corresponding change in the size of the primary visual area. Furthermore, elimination of most thalamocortical projections from the outset of their development resulted in altered areal gene expression patterns, particularly in the primary visual and somatosensory areas, where they lost sharp boundaries with adjacent areas. Together, these results demonstrate the critical roles of thalamic afferents in the establishment of neocortical areas.

Original languageEnglish (US)
Pages (from-to)8442-8453
Number of pages12
JournalJournal of Neuroscience
Issue number19
StatePublished - 2013


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