Tetrahydrobenzochromene Synthesis Enabled by a Deconjugative Alkylation/Tsuji-Saegusa-Ito Oxidation on Knoevenagel Adducts

Primali V. Navaratne; Alexander J. Grenning

doi:10.1021/acs.orglett.8b01857

Tetrahydrobenzochromene Synthesis Enabled by a Deconjugative Alkylation/Tsuji-Saegusa-Ito Oxidation on Knoevenagel Adducts

Primali V. Navaratne
, Alexander J. Grenning

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A modular and practical route to versatile cyano-1,3-dienes by a sequence involving deconjugative alkylation and "Tsuji-Saegusa-Ito oxidation" is reported. In this letter, the versatility of the products is also explored, including a route to benzochromene scaffolds common to many natural products.

Original language	English (US)
Pages (from-to)	4566-4570
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.8b01857
State	Published - Aug 3 2018
Externally published	Yes

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© 2018 American Chemical Society.

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AU - Grenning, Alexander J.

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AB - A modular and practical route to versatile cyano-1,3-dienes by a sequence involving deconjugative alkylation and "Tsuji-Saegusa-Ito oxidation" is reported. In this letter, the versatility of the products is also explored, including a route to benzochromene scaffolds common to many natural products.

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Tetrahydrobenzochromene Synthesis Enabled by a Deconjugative Alkylation/Tsuji-Saegusa-Ito Oxidation on Knoevenagel Adducts

Abstract

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