Tetanus vaccination and risk of multiple sclerosis: A systematic review

Miguel A. Hernán, Alvaro Alonso, Sonia Hernández-Díaz

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


OBJECTIVE: To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS: The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following inclusion criteria: presentation of original data, case-control or cohort design, physician-confirmed diagnosis of MS as the outcome of interest, attempt to ascertain vaccinations in a period before the diagnosis, and report of an association measure between tetanus vaccination and incidence of MS, and its 95% CI or enough information to compute it. Study specific log ORs were weighted by the inverse of their variances to obtain a pooled estimate and its 95% CI. RESULTS: The OR of MS associated with history of tetanus vaccination was 0.67 (95% CI: 0.55 to 0.81). There was little indication of heterogeneity of results across studies. CONCLUSION: Tetanus vaccination is associated with a lower risk of multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
Issue number2
StatePublished - Jul 2006
Externally publishedYes


Dive into the research topics of 'Tetanus vaccination and risk of multiple sclerosis: A systematic review'. Together they form a unique fingerprint.

Cite this