Abstract
Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 619-624 |
| Number of pages | 6 |
| Journal | ACS Applied Bio Materials |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 18 2019 |
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Keywords
- carbohydrates
- epidermolysis bullosa
- Forcespinning
- nanofibers
- wound healing
How much support was provided by MRSEC?
- Shared
Reporting period for MRSEC
- Period 5
Cite this
Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration. / Boyle, William S.; Chen, Weili; Rodriguez, Astrid; Linn, Samantha; Tolar, Jakub; Lozano, Karen; Reineke, Theresa M.
In: ACS Applied Bio Materials, Vol. 2, No. 2, 18.02.2019, p. 619-624.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration
AU - Boyle, William S.
AU - Chen, Weili
AU - Rodriguez, Astrid
AU - Linn, Samantha
AU - Tolar, Jakub
AU - Lozano, Karen
AU - Reineke, Theresa M.
PY - 2019/2/18
Y1 - 2019/2/18
N2 - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.
AB - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.
KW - carbohydrates
KW - epidermolysis bullosa
KW - Forcespinning
KW - nanofibers
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85072768449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072768449&partnerID=8YFLogxK
U2 - 10.1021/acsabm.8b00690
DO - 10.1021/acsabm.8b00690
M3 - Article
VL - 2
SP - 619
EP - 624
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
SN - 2576-6422
IS - 2
ER -