Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

Research output: Contribution to journalArticle

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalACS Applied Bio Materials
Volume2
Issue number2
DOIs
StatePublished - Feb 18 2019

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Epidermolysis Bullosa Dystrophica
Nanofibers
Chondroitin Sulfates
Chemokines
Cell Movement
Squamous Cell Carcinoma
Fibers
Tannins
Composite materials
Hydration
Acids
Water
Wounds and Injuries
Bandages
Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate
Epithelial Cells
Sulfates
Carcinogenesis
Inflammation
Weights and Measures

Keywords

  • carbohydrates
  • epidermolysis bullosa
  • Forcespinning
  • nanofibers
  • wound healing

How much support was provided by MRSEC?

  • Shared

Reporting period for MRSEC

  • Period 5

Cite this

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title = "Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration",
abstract = "Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500{\%} their weight in water. The fibers remove ∼99{\%} of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.",
keywords = "carbohydrates, epidermolysis bullosa, Forcespinning, nanofibers, wound healing",
author = "Boyle, {William S.} and Weili Chen and Astrid Rodriguez and Samantha Linn and Jakub Tolar and Karen Lozano and Reineke, {Theresa M.}",
year = "2019",
month = "2",
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doi = "10.1021/acsabm.8b00690",
language = "English (US)",
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pages = "619--624",
journal = "ACS Applied Bio Materials",
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TY - JOUR

T1 - Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

AU - Boyle, William S.

AU - Chen, Weili

AU - Rodriguez, Astrid

AU - Linn, Samantha

AU - Tolar, Jakub

AU - Lozano, Karen

AU - Reineke, Theresa M.

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

AB - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

KW - carbohydrates

KW - epidermolysis bullosa

KW - Forcespinning

KW - nanofibers

KW - wound healing

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DO - 10.1021/acsabm.8b00690

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