Terminally exhausted CD8⁺ T cells contribute to age-dependent severity of respiratory virus infection

Keyphrases

• CD8+ T Cells 100%
• Age-dependent 100%
• Respiratory Infection 100%
• Human Metapneumovirus (hMPV) 66%
• Older Adults 33%
• Aged Mice 33%
• Lung 16%
• Influenza 16%
• T Cells 16%
• Weight Loss 16%
• C57BL 16%
• Programmed Death-ligand 1 (PD-L1) 16%
• Functional Impairment 16%
• Severe Disease 16%
• Epitope 16%
• Clinical Disease 16%
• Respiratory Pathogens 16%
• Viral Infection 16%
• Adoptive Transfer 16%
• High-level Expression 16%
• Respiratory Viral Infection 16%
• Adult Mice 16%
• Seropositivity 16%
• Inhibitory Receptors 16%
• RAG1 16%
• Severe Respiratory Failure 16%
• Lung Pathology 16%
• Eomes 16%
• Infection-specific 16%
• CD8+ T Cell Exhaustion 16%
• Aged Mouse Model 16%
• TCF1 16%
• Age-associated 16%
• Cell-intrinsic 16%
• Severe Morbidity 16%
• Lower Respiratory Infections 16%
• Delayed Viral Clearance 16%

Immunology and Microbiology

• Cytotoxic T-Cell 100%
• Viral Disease 100%
• Respiratory Virus 100%
• Human Metapneumovirus 57%
• Mouse 42%
• Influenza 14%
• Monospecific Antibody 14%
• Seropositivity 14%
• Transplant Procedure 14%
• Infectious Agent 14%
• Mouse Model 14%
• Epitope 14%
• Viral Clearance 14%
• C57BL 6 Mouse 14%
• T Cell 14%