Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors

Deena M. Wassenberg; Richard T. Di Giulio

doi:10.1016/j.marenvres.2004.03.012

Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors

Deena M. Wassenberg
, Richard T. Di Giulio

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.

Original language	English (US)
Pages (from-to)	163-168
Number of pages	6
Journal	Marine Environmental Research
Volume	58
Issue number	2-5
DOIs	https://doi.org/10.1016/j.marenvres.2004.03.012
State	Published - Aug 2004
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the Superfund Basic Research Programs GrantP42 ES10356 (R.T.D.) and an EPA STAR fellowship (D.M.W.).

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10.1016/j.marenvres.2004.03.012

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title = "Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors",

abstract = "The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.",

author = "Wassenberg, \{Deena M.\} and \{Di Giulio\}, \{Richard T.\}",

note = "Funding Information: This research was supported by the Superfund Basic Research Programs GrantP42 ES10356 (R.T.D.) and an EPA STAR fellowship (D.M.W.).",

year = "2004",

month = aug,

doi = "10.1016/j.marenvres.2004.03.012",

language = "English (US)",

volume = "58",

pages = "163--168",

journal = "Marine Environmental Research",

issn = "0141-1136",

publisher = "Elsevier Ltd",

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T1 - Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors

AU - Wassenberg, Deena M.

AU - Di Giulio, Richard T.

N1 - Funding Information: This research was supported by the Superfund Basic Research Programs GrantP42 ES10356 (R.T.D.) and an EPA STAR fellowship (D.M.W.).

PY - 2004/8

Y1 - 2004/8

N2 - The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.

AB - The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.

UR - https://www.scopus.com/pages/publications/2942544706

UR - https://www.scopus.com/pages/publications/2942544706#tab=citedBy

U2 - 10.1016/j.marenvres.2004.03.012

DO - 10.1016/j.marenvres.2004.03.012

M3 - Article

C2 - 15178029

AN - SCOPUS:2942544706

SN - 0141-1136

VL - 58

SP - 163

EP - 168

JO - Marine Environmental Research

JF - Marine Environmental Research

IS - 2-5

ER -

Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors

Abstract

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