TY - JOUR
T1 - Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors
AU - Wassenberg, Deena M.
AU - Di Giulio, Richard T.
N1 - Funding Information:
This research was supported by the Superfund Basic Research Programs GrantP42 ES10356 (R.T.D.) and an EPA STAR fellowship (D.M.W.).
PY - 2004/8
Y1 - 2004/8
N2 - The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.
AB - The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.
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U2 - 10.1016/j.marenvres.2004.03.012
DO - 10.1016/j.marenvres.2004.03.012
M3 - Article
C2 - 15178029
AN - SCOPUS:2942544706
SN - 0141-1136
VL - 58
SP - 163
EP - 168
JO - Marine Environmental Research
JF - Marine Environmental Research
IS - 2-5
ER -