Tensile and shear methods for measuring strength of bilayer tablets

Shao Yu Chang, Jian xin Li, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear force application. Moreover, data obtained from the shear method depend on the orientation of the bilayer tablet. Although more time-consuming to perform, the tensile method yields data that are straightforward to interpret. Thus, the tensile method is preferred in fundamental bilayer tableting research to minimize ambiguity in data interpretation. Using both shear and tensile methods, we measured the mechanical strength of bilayer tablets made of several different layer combinations of lactose and microcrystalline cellulose. We observed a good correlation between strength obtained by the tensile method and carefully conducted shear method. This suggests that the shear method may be used for routine quality test of bilayer tablets during manufacturing because of its speed and convenience, provided a protocol for careful control of the placement of the tablet interface, tablet orientation, and blade is implemented.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalInternational journal of pharmaceutics
Issue number1
StatePublished - May 15 2017


  • Bilayer
  • Lactose
  • Mechanical properties
  • Microcrystalline cellulose
  • Shear
  • Tablet
  • Tensile


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