Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men

Jerilynn C. Prior; Lisa Langsetmo; Brian C. Lentle; Claudie Berger; David Goltzman; Christopher S. Kovacs; Stephanie M. Kaiser; Jonathan D. Adachi; Alexandra Papaioannou; Tassos Anastassiades; Tanveer Towheed; Robert G. Josse; Jacques P. Brown; William D. Leslie; Nancy Kreiger; Alan Tenenhouse; Suzette Poliquin; Suzanne Godmaire; Silvia Dumont; Brian Lentle; Louise Mailloux; Diane Bastien; Loralee Robertson; Carol Joyce; Christopher Kovacs; Emma Sheppard; Susan Kirkland; Stephanie Kaiser; Barbara Stanfield; Louis Bessette; Marc Gendreau; Wilma Hopman; Karen Rees-Milton; Robert Josse; Sophie Jamal; Angela M. Cheung; Barbara Gardner-Bray; Laura Pickard; P. Wojciech; [No Value] Olszynski; K. Shawn Davison; Jola Thingvold; David A. Hanley; Steven Boyd; Jane Allan; Millan Patel; Yvette M. Vigna; Nerkeza Andjelic; [No Value] ElhamRahme; Brent Richards; Suzanne Morin; Stuart Jackson

doi:10.1016/j.bone.2014.10.026

Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men

Jerilynn C. Prior, Lisa Langsetmo, Brian C. Lentle, Claudie Berger, David Goltzman, Christopher S. Kovacs, Stephanie M. Kaiser, Jonathan D. Adachi, Alexandra Papaioannou, Tassos Anastassiades, Tanveer Towheed, Robert G. Josse, Jacques P. Brown, William D. Leslie, Nancy Kreiger, Alan Tenenhouse, Suzette Poliquin, Suzanne Godmaire, Silvia Dumont, Brian LentleLouise Mailloux, Diane Bastien, Loralee Robertson, Carol Joyce, Christopher Kovacs, Emma Sheppard, Susan Kirkland, Stephanie Kaiser, Barbara Stanfield, Louis Bessette, Marc Gendreau, Wilma Hopman, Karen Rees-Milton, Robert Josse, Sophie Jamal, Angela M. Cheung, Barbara Gardner-Bray, Laura Pickard, P. Wojciech, [No Value] Olszynski, K. Shawn Davison, Jola Thingvold, David A. Hanley, Steven Boyd, Jane Allan, Millan Patel, Yvette M. Vigna, Nerkeza Andjelic, [No Value] ElhamRahme, Brent Richards, Suzanne Morin, Stuart Jackson

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.

Original language	English (US)
Pages (from-to)	237-243
Number of pages	7
Journal	Bone
Volume	71
DOIs	https://doi.org/10.1016/j.bone.2014.10.026
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc.

Keywords

10-year fracture incidence
Clinical vertebral fracture
Fracture prediction
Hip fracture
Population-based
Sex

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10.1016/j.bone.2014.10.026

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Prior, J. C., Langsetmo, L., Lentle, B. C., Berger, C., Goltzman, D., Kovacs, C. S., Kaiser, S. M., Adachi, J. D., Papaioannou, A., Anastassiades, T., Towheed, T., Josse, R. G., Brown, J. P., Leslie, W. D., Kreiger, N., Tenenhouse, A., Poliquin, S., Godmaire, S., Dumont, S., ... Jackson, S. (2015). Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men. Bone, 71, 237-243. https://doi.org/10.1016/j.bone.2014.10.026

Prior, JC, Langsetmo, L, Lentle, BC, Berger, C, Goltzman, D, Kovacs, CS, Kaiser, SM, Adachi, JD, Papaioannou, A, Anastassiades, T, Towheed, T, Josse, RG, Brown, JP, Leslie, WD, Kreiger, N, Tenenhouse, A, Poliquin, S, Godmaire, S, Dumont, S, Lentle, B, Mailloux, L, Bastien, D, Robertson, L, Joyce, C, Kovacs, C, Sheppard, E, Kirkland, S, Kaiser, S, Stanfield, B, Bessette, L, Gendreau, M, Hopman, W, Rees-Milton, K, Josse, R, Jamal, S, Cheung, AM, Gardner-Bray, B, Pickard, L, Wojciech, P, Olszynski, NV, Davison, KS, Thingvold, J, Hanley, DA, Boyd, S, Allan, J, Patel, M, Vigna, YM, Andjelic, N, ElhamRahme, NV, Richards, B, Morin, S & Jackson, S 2015, 'Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men', Bone, vol. 71, pp. 237-243. https://doi.org/10.1016/j.bone.2014.10.026

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title = "Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men",

abstract = "Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.",

keywords = "10-year fracture incidence, Clinical vertebral fracture, Fracture prediction, Hip fracture, Population-based, Sex",

author = "Prior, {Jerilynn C.} and Lisa Langsetmo and Lentle, {Brian C.} and Claudie Berger and David Goltzman and Kovacs, {Christopher S.} and Kaiser, {Stephanie M.} and Adachi, {Jonathan D.} and Alexandra Papaioannou and Tassos Anastassiades and Tanveer Towheed and Josse, {Robert G.} and Brown, {Jacques P.} and Leslie, {William D.} and Nancy Kreiger and Alan Tenenhouse and Suzette Poliquin and Suzanne Godmaire and Silvia Dumont and Brian Lentle and Louise Mailloux and Diane Bastien and Loralee Robertson and Carol Joyce and Christopher Kovacs and Emma Sheppard and Susan Kirkland and Stephanie Kaiser and Barbara Stanfield and Louis Bessette and Marc Gendreau and Wilma Hopman and Karen Rees-Milton and Robert Josse and Sophie Jamal and Cheung, {Angela M.} and Barbara Gardner-Bray and Laura Pickard and P. Wojciech and Olszynski, {[No Value]} and Davison, {K. Shawn} and Jola Thingvold and Hanley, {David A.} and Steven Boyd and Jane Allan and Millan Patel and Vigna, {Yvette M.} and Nerkeza Andjelic and ElhamRahme, {[No Value]} and Brent Richards and Suzanne Morin and Stuart Jackson",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2015",

doi = "10.1016/j.bone.2014.10.026",

language = "English (US)",

volume = "71",

pages = "237--243",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men

AU - Prior, Jerilynn C.

AU - Langsetmo, Lisa

AU - Lentle, Brian C.

AU - Berger, Claudie

AU - Goltzman, David

AU - Kovacs, Christopher S.

AU - Kaiser, Stephanie M.

AU - Adachi, Jonathan D.

AU - Papaioannou, Alexandra

AU - Anastassiades, Tassos

AU - Towheed, Tanveer

AU - Josse, Robert G.

AU - Brown, Jacques P.

AU - Leslie, William D.

AU - Kreiger, Nancy

AU - Tenenhouse, Alan

AU - Poliquin, Suzette

AU - Godmaire, Suzanne

AU - Dumont, Silvia

AU - Lentle, Brian

AU - Mailloux, Louise

AU - Bastien, Diane

AU - Robertson, Loralee

AU - Joyce, Carol

AU - Kovacs, Christopher

AU - Sheppard, Emma

AU - Kirkland, Susan

AU - Kaiser, Stephanie

AU - Stanfield, Barbara

AU - Bessette, Louis

AU - Gendreau, Marc

AU - Hopman, Wilma

AU - Rees-Milton, Karen

AU - Josse, Robert

AU - Jamal, Sophie

AU - Cheung, Angela M.

AU - Gardner-Bray, Barbara

AU - Pickard, Laura

AU - Wojciech, P.

AU - Olszynski, [No Value]

AU - Davison, K. Shawn

AU - Thingvold, Jola

AU - Hanley, David A.

AU - Boyd, Steven

AU - Allan, Jane

AU - Patel, Millan

AU - Vigna, Yvette M.

AU - Andjelic, Nerkeza

AU - ElhamRahme, [No Value]

AU - Richards, Brent

AU - Morin, Suzanne

AU - Jackson, Stuart

PY - 2015

Y1 - 2015

N2 - Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.

AB - Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.

KW - 10-year fracture incidence

KW - Clinical vertebral fracture

KW - Fracture prediction

KW - Hip fracture

KW - Population-based

KW - Sex

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DO - 10.1016/j.bone.2014.10.026

M3 - Article

C2 - 25451323

AN - SCOPUS:84912051938

SN - 8756-3282

VL - 71

SP - 237

EP - 243

JO - Bone

JF - Bone

ER -

Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men

Abstract

Bibliographical note

Keywords

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