Temporal trends in syphilis and gonorrhea incidences in Guangdong Province, China

Nicholas X. Tan, Grace X. Tan, Li Gang Yang, Bin Yang, Kimberly A. Powers, Michael E. Emch, Joseph D. Tucker

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The high burden of syphilis in China presents a unique opportunity to examine temporal trends. This study used wavelet transformation and Fourier analysis to assess the presence of temporal oscillations in the incidence of syphilis among adults, gonorrhea, and congenital syphilis over 11 years in China's largest province. This study found a significant annual oscillation trend in the incidence of adult syphilis, consistent with a peak during July-September, which was 4-fold higher than the trough, which occurred during January-March. A similar but dampened trend was observed in the incidence of gonorrhea, and no trend was observed for the incidence of congenital syphilis. Further research on the temporal oscillation of the incidence of syphilis is needed.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
StatePublished - 2014
Externally publishedYes

Bibliographical note

Funding Information:
Financial support. This work was supported by the National Institutes of Health (Fogarty award 1K01TW008200-01A1), the Guangdong Provincial STI Control Center, and the Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene Wellcome Junior Faculty Award in Tropical Infectious Diseases. Potential conflicts of interest. All authors: No reported conflicts.


  • Fourier transform
  • disease dynamics
  • gonorrhea
  • immunity
  • oscillation
  • syphilis
  • wavelet


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