Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers

Timothy R Church, Kristin E Anderson, Chap T Le, Yan Zhang, Diane M. Kampa, Adam R. Benoit, Andrea R. Yoder, Steven G Carmella, Stephen S Hecht

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Intraindividual variability of measurements of 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanol (NNAL), nicotine, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1, 2,3,4-tetrahydrophenanthrene (PheT) over time is uncertain. From 70 habitual smokers' plasma and urine sampled bimonthly for a year we analysed plasma for NNAL, cotinine and PheT, and urine for NNAL, cotinine and nicotine. We estimated the intraclass correlation coefficients (ρI) for each measurement. Plasma and creatinine-corrected urinary NNAL were stable (ρI ≥70%); plasma PheT and plasma and urinary total cotinine were fairly stable (ρI ≥50%), but urinary nicotine ρI ≈ 40% was not. Except for nicotine, single measurements from plasma or urine adequately represent individual mean exposure over time.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalBiomarkers
Volume15
Issue number4
DOIs
StatePublished - Jun 2010

Keywords

  • Intraclass correlation coefficient
  • NNAL
  • NNK
  • Phenanthrene tetraol
  • Tobacco carcinogens

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